{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["28(9)"],"submitter":["Keller F"],"funding":["German Research Foundation"],"pubmed_abstract":["Natural killer (NK) cell responses are modulated by type-I interferons (IFNs) in viral infection. Chronic hepatitis C virus (HCV) infection, marked by robust IFN signatures, shows NK cells with reduced cytokine release but heightened cytotoxicity. Comparable alterations occur in chronic hepatitis B virus (HBV) infection even without a pronounced IFN milieu, implying additional regulatory layers. We analyzed NK cells from healthy donors and patients with chronic HBV or HCV and found conserved expression patterns of interferon-stimulated genes (ISGs) such as <i>IFITM3</i>, <i>IRF1</i>, <i>IFIT2,</i> and <i>ISG20</i> that correlated with NK cell differentiation state. These genes are governed by fate-determining transcription factors, including ETS1, FLI1, and Eomes, and appear to be constitu"],"journal":["iScience"],"pagination":["113216"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12362017"],"repository":["biostudies-literature"],"pubmed_title":["Differentiation-associated ISG expression of NK cells in chronic viral infection."],"pmcid":["PMC12362017"],"pubmed_authors":["Sogukpinar O","Rizzi M","Eils R","Thimme R","Hofmann M","Lohmann V","Boettler T","Bengsch B","Beier F","Bauersfeld L","Sagar","Neumann-Haefelin C","Binder M","Keller F","Trefzer T","Jechow K","Rusignuolo G","Pichlmair A","Conrad C","Chua RL"],"additional_accession":[]},"is_claimable":false,"name":"Differentiation-associated ISG expression of NK cells in chronic viral infection.","description":"Natural killer (NK) cell responses are modulated by type-I interferons (IFNs) in viral infection. Chronic hepatitis C virus (HCV) infection, marked by robust IFN signatures, shows NK cells with reduced cytokine release but heightened cytotoxicity. Comparable alterations occur in chronic hepatitis B virus (HBV) infection even without a pronounced IFN milieu, implying additional regulatory layers. We analyzed NK cells from healthy donors and patients with chronic HBV or HCV and found conserved expression patterns of interferon-stimulated genes (ISGs) such as <i>IFITM3</i>, <i>IRF1</i>, <i>IFIT2,</i> and <i>ISG20</i> that correlated with NK cell differentiation state. These genes are governed by fate-determining transcription factors, including ETS1, FLI1, and Eomes, and appear to be constitu","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-07-15T05:56:11.158Z","creation":"2026-06-30T03:20:22.796Z"},"accession":"S-EPMC12362017","cross_references":{"pubmed":["40837234"],"doi":["10.1016/j.isci.2025.113216"]}}