{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rengel KF"],"funding":["NCATS NIH HHS","NIA NIH HHS","NHLBI NIH HHS","NIGMS NIH HHS"],"pagination":["100115"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12363371"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3(2)"],"pubmed_abstract":["<h4>Background</h4>Factors associated with disability after critical illness are incompletely understood. Lower pre-existing muscle mass and muscle density on CT imaging are associated with greater mortality resulting from critical illness. Their relationship with disability and physical function in survivors of critical illness is unclear.<h4>Research question</h4>We sought to understand the relationship between muscle mass and muscle density before critical illness and disability and self-reported physical function after surviving a critical illness.<h4>Study design and methods</h4>We conducted a nested cohort study of 125 survivors of critical illness with abdominal imaging between 6 months before and 4 days after ICU admission. We measured skeletal muscle cross-sectional area at the L3"],"journal":["CHEST critical care"],"pubmed_title":["Associations Among Skeletal Muscle Health, Disability, and Self-Reported Physical Function in Survivors of Critical Illness: A Secondary Analysis of the Bringing to Light the Risk Factors and Incidence of Neuropsychological Dysfunction in ICU Survivors Study."],"pmcid":["PMC12363371"],"funding_grant_id":["R01 AG061161","R61 HL151951","KL2 TR002245","R01 AG053582","R01 AG027472","R01 GM120484","R33 HL151951","R01 HL111111","K76 AG054864"],"pubmed_authors":["Brummel NE","Mart MF","Jackson JC","Ely EW","Wilson JE","Orun OM","Rengel KF","Hollingsworth E","Silver HJ","Hughes CG"],"additional_accession":[]},"is_claimable":false,"name":"Associations Among Skeletal Muscle Health, Disability, and Self-Reported Physical Function in Survivors of Critical Illness: A Secondary Analysis of the Bringing to Light the Risk Factors and Incidence of Neuropsychological Dysfunction in ICU Survivors Study.","description":"<h4>Background</h4>Factors associated with disability after critical illness are incompletely understood. Lower pre-existing muscle mass and muscle density on CT imaging are associated with greater mortality resulting from critical illness. Their relationship with disability and physical function in survivors of critical illness is unclear.<h4>Research question</h4>We sought to understand the relationship between muscle mass and muscle density before critical illness and disability and self-reported physical function after surviving a critical illness.<h4>Study design and methods</h4>We conducted a nested cohort study of 125 survivors of critical illness with abdominal imaging between 6 months before and 4 days after ICU admission. We measured skeletal muscle cross-sectional area at the L3","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jun","modification":"2026-05-29T17:05:55.79Z","creation":"2026-04-08T05:24:49.065Z"},"accession":"S-EPMC12363371","cross_references":{"pubmed":["40837197"],"doi":["10.1016/j.chstcc.2024.100115"]}}