{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Uchida D"],"funding":["Japan Science and Technology Agency","Japan Society for the Promotion of Science"],"pagination":["e202508927"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12363641"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["64(34)"],"pubmed_abstract":["We report the properties and reactivity of an unprecedented methylene-bridged 1,3-bis(germylene) derivative. In the solid state, it undergoes dimerization to afford a 1,2,4,5-tetragermacyclohexa-1,4-diene derivative (Ge<sub>4</sub>CHD). Moreover, theoretical calculations on Ge<sub>4</sub>CHD reveal σ*-π interactions between the two π orbitals (Ge═Ge) and the CH σ* orbital. This interaction is confirmed by a significant red shift in the solid-state UV-vis spectrum. In contrast to the behavior in the solid state, the Ge<sub>4</sub>CHD derivative dissociates in solution into a methylene-bridged 1,3-bis(germylene) derivative. The resultant 1,3-bis(germylene) derivative reacted with S<sub>8</sub> to form a novel cage compound containing three S and two Ge atoms. On the other hand, in the reaction with triphenylphosphine sulfide, the in situ generated 2-thia-1,3-digermabicyclo[1.1.0]butane derivative activated the benzene solvent, leading to the formation of a [2 + 2] cycloaddition product. Additionally, the 1,3-bis(germylene) derivative reacted with 4-dimethylaminopyridine (DMAP) to form a three-membered ring. Its structural parameters and the results of theoretical calculations indicated the zwitterionic character."],"journal":["Angewandte Chemie (International ed. in English)"],"pubmed_title":["Reactivity of a Methylene-Bridged 1,3-Bis(germylene) in Dynamic Equilibrium with Its Dimer."],"pmcid":["PMC12363641"],"funding_grant_id":["25H02026","JPMJFS2123","24K01496","19H05635","18H01963","22K14665"],"pubmed_authors":["Mizuhata Y","Yamauchi M","Tokitoh N","Yukimoto M","Yamada H","Uchida D"],"additional_accession":[]},"is_claimable":false,"name":"Reactivity of a Methylene-Bridged 1,3-Bis(germylene) in Dynamic Equilibrium with Its Dimer.","description":"We report the properties and reactivity of an unprecedented methylene-bridged 1,3-bis(germylene) derivative. In the solid state, it undergoes dimerization to afford a 1,2,4,5-tetragermacyclohexa-1,4-diene derivative (Ge<sub>4</sub>CHD). Moreover, theoretical calculations on Ge<sub>4</sub>CHD reveal σ*-π interactions between the two π orbitals (Ge═Ge) and the CH σ* orbital. This interaction is confirmed by a significant red shift in the solid-state UV-vis spectrum. In contrast to the behavior in the solid state, the Ge<sub>4</sub>CHD derivative dissociates in solution into a methylene-bridged 1,3-bis(germylene) derivative. The resultant 1,3-bis(germylene) derivative reacted with S<sub>8</sub> to form a novel cage compound containing three S and two Ge atoms. On the other hand, in the reaction with triphenylphosphine sulfide, the in situ generated 2-thia-1,3-digermabicyclo[1.1.0]butane derivative activated the benzene solvent, leading to the formation of a [2 + 2] cycloaddition product. Additionally, the 1,3-bis(germylene) derivative reacted with 4-dimethylaminopyridine (DMAP) to form a three-membered ring. Its structural parameters and the results of theoretical calculations indicated the zwitterionic character.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-01T01:42:50.444Z","creation":"2026-04-07T16:33:25.646Z"},"accession":"S-EPMC12363641","cross_references":{"pubmed":["40545949"],"doi":["10.1002/anie.202508927"]}}