{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Saji M"],"funding":["Rutgers University","Faculty Early Career Development Award","National Science Foundation"],"pagination":["e202507844"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12363646"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["64(34)"],"pubmed_abstract":["Hydrophobic interactions are one of the fundamental driving forces of self-assembly in living systems. It remains challenging to harness hydrophobicity to have a controllable and programmable assembly of DNA nanostructures. On the other hand, there is also a need to explore orthogonal hierarchical assembly strategies to be used as an additional toolset along with the traditional Watson-Crick base pairing to achieve complex superstructures. In this work, we rationally design and synthesize a series of low molecular weight hydrophobic molecules that are conjugated to single-stranded DNA strands. By incorporating these modified DNA strands into the precisely defined locations of DNA tiles and origami nanostructures, we achieve controlled hierarchical assembly driven by hydrophobic interaction"],"journal":["Angewandte Chemie (International ed. in English)"],"pubmed_title":["Controlling Assembly of Hybrid DNA Nanostructures into Higher-Order Structures via Hydrophobicity."],"pmcid":["PMC12363646"],"funding_grant_id":["DMR-2046835"],"pubmed_authors":["Saji M","Perumal D","Zhang F","Yang Q","Jaekle F"],"additional_accession":[]},"is_claimable":false,"name":"Controlling Assembly of Hybrid DNA Nanostructures into Higher-Order Structures via Hydrophobicity.","description":"Hydrophobic interactions are one of the fundamental driving forces of self-assembly in living systems. It remains challenging to harness hydrophobicity to have a controllable and programmable assembly of DNA nanostructures. On the other hand, there is also a need to explore orthogonal hierarchical assembly strategies to be used as an additional toolset along with the traditional Watson-Crick base pairing to achieve complex superstructures. In this work, we rationally design and synthesize a series of low molecular weight hydrophobic molecules that are conjugated to single-stranded DNA strands. By incorporating these modified DNA strands into the precisely defined locations of DNA tiles and origami nanostructures, we achieve controlled hierarchical assembly driven by hydrophobic interaction","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-04-13T17:10:42.495Z","creation":"2026-04-07T13:34:20.709Z"},"accession":"S-EPMC12363646","cross_references":{"pubmed":["40552795"],"doi":["10.1002/anie.202507844"]}}