{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["38"],"submitter":["Kourounis G"],"pubmed_abstract":["Understanding which factors shape long-term pancreas graft outcomes after the critical first year post-transplantation is an ongoing challenge. This study assesses one-year HbA1c as a predictor of subsequent pancreas graft survival. A retrospective cohort study was conducted using the UNOS registry on all simultaneous pancreas-kidney (SPK) transplants between 2017 and 2023. Regression models with multiple imputations for missing data were used to evaluate predictors of long-term function. Non-linear relationships were modelled with restricted cubic splines (RCS). Among 2,917 SPK recipients (median follow-up 44 months, IQR: 25-60), one-year HbA1c was the strongest independent predictor of long-term graft survival. An HbA1c of 6.8% versus 4.4% (95th vs. 5th percentile) was associated with si"],"journal":["Transplant international : official journal of the European Society for Organ Transplantation"],"pagination":["14940"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12364725"],"repository":["biostudies-literature"],"pubmed_title":["One-Year HbA1c Predicts Long-Term Pancreas Graft Survival Following SPK Transplantation: A US Population Cohort Study."],"pmcid":["PMC12364725"],"pubmed_authors":["Wadhera V","Wroe C","Kourounis G","Owen R","White S","Thompson ER","Zeeshan Akhtar M","van Leeuwen L","Tingle SJ","Wilson C","Maillo-Nieto A","Florman S","Holzner M","Shaw J"],"additional_accession":[]},"is_claimable":false,"name":"One-Year HbA1c Predicts Long-Term Pancreas Graft Survival Following SPK Transplantation: A US Population Cohort Study.","description":"Understanding which factors shape long-term pancreas graft outcomes after the critical first year post-transplantation is an ongoing challenge. This study assesses one-year HbA1c as a predictor of subsequent pancreas graft survival. A retrospective cohort study was conducted using the UNOS registry on all simultaneous pancreas-kidney (SPK) transplants between 2017 and 2023. Regression models with multiple imputations for missing data were used to evaluate predictors of long-term function. Non-linear relationships were modelled with restricted cubic splines (RCS). Among 2,917 SPK recipients (median follow-up 44 months, IQR: 25-60), one-year HbA1c was the strongest independent predictor of long-term graft survival. An HbA1c of 6.8% versus 4.4% (95th vs. 5th percentile) was associated with si","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-05-07T00:15:22.63Z","creation":"2026-04-07T22:21:34.324Z"},"accession":"S-EPMC12364725","cross_references":{"pubmed":["40843099"],"doi":["10.3389/ti.2025.14940"]}}