biostudies-literatureFerles ANational Institute for Health Research (NIHR)Swedish Governmentvdaf154https://www.ebi.ac.uk/biostudies/studies/S-EPMC12365902biostudies-literatureUnknown7(1)Accurate prognosis of glioblastoma is crucial for better-informed treatment decisions, potentially leading to improved disease management. We investigated whether clinical variables, tumor size, and location, can serve as prognostic factors. A retrospective, multicenter study enrolled 1318 adult patients with histopathologically confirmed glioblastoma undergoing first-time surgery, with survival censored for 188 patients. Pre-operative brain MRIs were used to compute tumor size and derive advanced radiological features describing tumor location, later refined by expert-based opinion. Post-operative MRIs were used to measure the enhancing residual tumor volume. The prognostic quality of all variables, measurements, and features was assessed as inputs of three survival regression models (CoxNeuro-oncology advancesEstimating overall survival of glioblastoma patients using clinical variables, tumor size, and location.PMC12365902ALFGBG-965622ALFGBG-1006089Bello LArdon HDunas THolden Helland RRossi MBarkhof FRobe PAReinertsen IKommers Ide Witt Hamer PCHervey-Jumper SLTewarie RNMandonnet ESagberg LMTranfa MAalders TWidhalm GZwinderman AHEijgelaar RSFurtner JBerger MSPedersen ASolheim OWagemakers MBouget DSciortino TThurin EKiesel BFerles AIdema AJSMajewska PNibali MCJakola ASfalseEstimating overall survival of glioblastoma patients using clinical variables, tumor size, and location.Accurate prognosis of glioblastoma is crucial for better-informed treatment decisions, potentially leading to improved disease management. We investigated whether clinical variables, tumor size, and location, can serve as prognostic factors. A retrospective, multicenter study enrolled 1318 adult patients with histopathologically confirmed glioblastoma undergoing first-time surgery, with survival censored for 188 patients. Pre-operative brain MRIs were used to compute tumor size and derive advanced radiological features describing tumor location, later refined by expert-based opinion. Post-operative MRIs were used to measure the enhancing residual tumor volume. The prognostic quality of all variables, measurements, and features was assessed as inputs of three survival regression models (Cox2025-01-01T00:00:00Z2025 Jan-Dec2026-05-07T00:24:42.753Z2026-04-07T22:21:09.82ZS-EPMC123659024084264210.1093/noajnl/vdaf154