{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang JE"],"funding":["University of Chicago","Juvenile Diabetes Research Foundation United States of America","NIDDK NIH HHS"],"pagination":["374"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12366006"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["Type 1 diabetes (T1D) is an autoimmune disease characterized by the destruction of insulin-producing pancreatic β-cells. Macrophages infiltrate islets early in T1D pathogenesis, preceding the influx of T- and B-lymphocytes. The integrated stress response (ISR), a cellular pathway activated during stress, coordinates adaptive changes in gene expression to maintain cell function and survival. To study the ISR in macrophages, bone-marrow-derived macrophages were treated with a pharmacological inhibitor of the ISR (ISRIB) and polarized to a proinflammatory M1-like state. We observed a reduction in the number of proinflammatory macrophages, as well as a decrease in iNOS mRNA and protein levels, following ISRIB treatment. RNA-sequencing revealed a reduction in pathways related to stress response"],"journal":["Cell communication and signaling : CCS"],"pubmed_title":["The integrated stress response promotes macrophage inflammation and migration in autoimmune diabetes."],"pmcid":["PMC12366006"],"funding_grant_id":["R01 DK135832","U01 DK127786","Quad Summer Scholarship","T32 AI153020","3-PDF-2023-1326-A-N"],"pubmed_authors":["Mirmira RG","Puente AA","Wang JE","Muralidharan C","Enriquez JR","Anderson RM","Nargis T","Tersey SA"],"additional_accession":[]},"is_claimable":false,"name":"The integrated stress response promotes macrophage inflammation and migration in autoimmune diabetes.","description":"Type 1 diabetes (T1D) is an autoimmune disease characterized by the destruction of insulin-producing pancreatic β-cells. Macrophages infiltrate islets early in T1D pathogenesis, preceding the influx of T- and B-lymphocytes. The integrated stress response (ISR), a cellular pathway activated during stress, coordinates adaptive changes in gene expression to maintain cell function and survival. To study the ISR in macrophages, bone-marrow-derived macrophages were treated with a pharmacological inhibitor of the ISR (ISRIB) and polarized to a proinflammatory M1-like state. We observed a reduction in the number of proinflammatory macrophages, as well as a decrease in iNOS mRNA and protein levels, following ISRIB treatment. RNA-sequencing revealed a reduction in pathways related to stress response","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-29T14:29:53.831Z","creation":"2026-04-08T05:05:32.454Z"},"accession":"S-EPMC12366006","cross_references":{"pubmed":["40836297"],"doi":["10.1186/s12964-025-02372-z"]}}