{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Welters K"],"funding":["Deutsche Forschungsgemeinschaft"],"pagination":["694-701"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12366286"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["46(11-12)"],"pubmed_abstract":["We present the coupling of capillary electrophoresis to a custom-built high-resolution ion mobility spectrometer (IMS). This system integrates a shifted inlet potential IMS configuration with a customised nanoflow ESI sheath interface. It enables the rapid analysis of quaternary ammonium compounds (QACs) and their impurities in real-world samples. It allowed the detection of six non-chromophoric compounds in about 3 min. The assignment of the IMS signals to compounds was supported by matching experimentally determined collision cross-section (CCS) values with predicted values. The system achieved a detection limit in the single-digit picogram range with IMS resolutions of over 80."],"journal":["Electrophoresis"],"pubmed_title":["Coupling Capillary Electrophoresis With a Shifted Inlet Potential High-Resolution Ion Mobility Spectrometer."],"pmcid":["PMC12366286"],"funding_grant_id":["458829155"],"pubmed_authors":["Schlottmann F","Zimmermann S","Belder D","Thoben C","Welters K","Raddatz CR"],"additional_accession":[]},"is_claimable":false,"name":"Coupling Capillary Electrophoresis With a Shifted Inlet Potential High-Resolution Ion Mobility Spectrometer.","description":"We present the coupling of capillary electrophoresis to a custom-built high-resolution ion mobility spectrometer (IMS). This system integrates a shifted inlet potential IMS configuration with a customised nanoflow ESI sheath interface. It enables the rapid analysis of quaternary ammonium compounds (QACs) and their impurities in real-world samples. It allowed the detection of six non-chromophoric compounds in about 3 min. The assignment of the IMS signals to compounds was supported by matching experimentally determined collision cross-section (CCS) values with predicted values. The system achieved a detection limit in the single-digit picogram range with IMS resolutions of over 80.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jun","modification":"2026-05-05T12:35:36.089Z","creation":"2026-04-07T21:42:16.674Z"},"accession":"S-EPMC12366286","cross_references":{"pubmed":["40292850"],"doi":["10.1002/elps.8147"]}}