{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ankur A"],"funding":["NIAID NIH HHS","National Institutes of Health","NIH HHS","NIGMS NIH HHS","National Science Foundation"],"pagination":["e202510409"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12366749"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["64(36)"],"pubmed_abstract":["Cryptococcus species are major fungal pathogens responsible for life-threatening infections in approximately a million individuals globally each year, with alarmingly high mortality rates. These fungi are distinguished by a distinctive cell wall architecture further reinforced by two virulence-associated layers, melanin and capsule, rendering them insensitive to antifungal agents targeting the cell wall, such as echinocandins. The molecular interplay between these three biomolecular layers remains poorly understood. Here, we employ solid-state NMR spectroscopy to examine intact cells of both wild-type and capsule-deficient strains of C. neoformans, along with melanized cells. High-resolution <sup>13</sup>C and <sup>1</sup>H data revealed five distinct structural forms of α-1,3-glucans that"],"journal":["Angewandte Chemie (International ed. in English)"],"pubmed_title":["Polymorphic α-Glucans as Structural Scaffolds in Cryptococcus Cell Walls for Chitin, Capsule, and Melanin: Insights From &lt;sup&gt;13&lt;/sup&gt;C and &lt;sup&gt;1&lt;/sup&gt;H Solid-State NMR."],"pmcid":["PMC12366749"],"funding_grant_id":["R21 AI175875","R21AI175875","R01 AI173270","R01 AI171093","RM1 GM148766","R01AI192892","DMR‐2128556","DMR-2128556","RM1‐GM148766","R01 AI192892","RM1-GM148766","R01AI171093","R01AI173270"],"pubmed_authors":["Yarava JR","Wang P","Roy D","Wang T","Ankur A","Mentink-Vigier F","Stark RE","Gautam I","Scott FJ","Chrissian C","Xie L","Doering TL"],"additional_accession":[]},"is_claimable":false,"name":"Polymorphic α-Glucans as Structural Scaffolds in Cryptococcus Cell Walls for Chitin, Capsule, and Melanin: Insights From &lt;sup&gt;13&lt;/sup&gt;C and &lt;sup&gt;1&lt;/sup&gt;H Solid-State NMR.","description":"Cryptococcus species are major fungal pathogens responsible for life-threatening infections in approximately a million individuals globally each year, with alarmingly high mortality rates. These fungi are distinguished by a distinctive cell wall architecture further reinforced by two virulence-associated layers, melanin and capsule, rendering them insensitive to antifungal agents targeting the cell wall, such as echinocandins. The molecular interplay between these three biomolecular layers remains poorly understood. Here, we employ solid-state NMR spectroscopy to examine intact cells of both wild-type and capsule-deficient strains of C. neoformans, along with melanized cells. High-resolution <sup>13</sup>C and <sup>1</sup>H data revealed five distinct structural forms of α-1,3-glucans that","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-29T22:00:48.994Z","creation":"2026-04-08T06:11:26.595Z"},"accession":"S-EPMC12366749","cross_references":{"pubmed":["40626985"],"doi":["10.1002/anie.202510409"]}}