{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Ding D"],"pubmed_abstract":["The incorporation of enantioenriched difluoromethyl cyclopropane (DFC) groups into drug candidates has garnered increasing attention in the pharmaceutical industry due to the unique ability of the DFC groups to serve as conformationally rigid hydrogen-bond donors. Despite their potential, the widespread use of chiral DFC groups has been limited by their challenging synthesis. Here we report the use of difluoromethyl-copper complexes for the development of a desymmetric difluoromethylation reaction, using enantioselective copper catalysis. Through desymmetric difluoromethylation of cyclopropenes and subsequent electrophilic functionalization, this method achieves high efficiency and enantioselectivity, enabling the modular construction of chiral DFC moieties. The synthetic utility of this s"],"journal":["Nature synthesis"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12366757"],"repository":["biostudies-literature"],"pubmed_title":["Synthesis of chiral difluoromethyl cyclopropanes through desymmetric difluoromethylation of cyclopropenes enabled by enantioselective copper catalysis."],"pmcid":["PMC12366757"],"pubmed_authors":["Krause JA","Ding D","Ou WT","Cheng MJ","Chen S","Yin L","Liu W"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis of chiral difluoromethyl cyclopropanes through desymmetric difluoromethylation of cyclopropenes enabled by enantioselective copper catalysis.","description":"The incorporation of enantioenriched difluoromethyl cyclopropane (DFC) groups into drug candidates has garnered increasing attention in the pharmaceutical industry due to the unique ability of the DFC groups to serve as conformationally rigid hydrogen-bond donors. Despite their potential, the widespread use of chiral DFC groups has been limited by their challenging synthesis. Here we report the use of difluoromethyl-copper complexes for the development of a desymmetric difluoromethylation reaction, using enantioselective copper catalysis. Through desymmetric difluoromethylation of cyclopropenes and subsequent electrophilic functionalization, this method achieves high efficiency and enantioselectivity, enabling the modular construction of chiral DFC moieties. The synthetic utility of this s","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 May","modification":"2026-05-09T00:07:47.103Z","creation":"2026-04-08T00:18:03.13Z"},"accession":"S-EPMC12366757","cross_references":{"pubmed":["40852334"],"doi":["10.1038/s44160-025-00809-4"]}}