{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["de Almeida MC"],"funding":["Fundação de Amparo à Pesquisa do Estado do Amazonas","Conselho Nacional de Desenvolvimento CientÃfico e Tecnológico","Instituto Nacional de Ciência e Tecnologia da Criosfera"],"pagination":["e0013423"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12367189"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(8)"],"pubmed_abstract":["Background
Bothrops atrox envenomation can cause significant local and systemic effects. Adjunctive therapies, such as cold and heat applications, are proposed to enhance antivenom efficacy, but their clinical value remains unclear.Methods
This randomized, three-arm clinical trial included 94 patients allocated in a 1:1:1 ratio to Cold Therapy Group (CTG, n = 30), Heat Therapy Group (HTG, n = 31), or Control Group (CG, n = 33). All participants received standard antivenom therapy, with CTG and HTG receiving additional interventions applied for 24 hours post-admission. Primary outcomes included changes in creatine kinase (CK) levels. Secondary outcomes assessed pain intensity, edema, local temperature, and functional recovery using the World Health Organization Disability As"],"journal":["PLoS neglected tropical diseases"],"pubmed_title":["Limited efficacy of cold and heat therapy as adjunctive treatments for local and functional outcomes of Bothrops atrox snakebite envenomation: A randomized clinical trial."],"pmcid":["PMC12367189"],"funding_grant_id":["call AMAZÔNIA+10","call No. 017/2023 – PRONEM","302662/2017-0","call No. 002/2021 PROGRAMA AMAZÔNIDAS – “Mulheres e Meninas na Ciência”","311434/2021–5","call No. 020/2024 - PROGRAMA PRODUTIVIDADE EM CT&I – EDIÇÃO 2024"],"pubmed_authors":["Mendes YDS","de Castro DB","Sachett JAG","Oliveira DN","Monteiro W","Araujo FQ","Carvalho EDS","Sartim MA","Almeida-Val F","Sachett A","Vissoci JRN","de Almeida MC","Carvalho KMP"],"additional_accession":[]},"is_claimable":false,"name":"Limited efficacy of cold and heat therapy as adjunctive treatments for local and functional outcomes of Bothrops atrox snakebite envenomation: A randomized clinical trial.","description":"Background
Bothrops atrox envenomation can cause significant local and systemic effects. Adjunctive therapies, such as cold and heat applications, are proposed to enhance antivenom efficacy, but their clinical value remains unclear.Methods
This randomized, three-arm clinical trial included 94 patients allocated in a 1:1:1 ratio to Cold Therapy Group (CTG, n = 30), Heat Therapy Group (HTG, n = 31), or Control Group (CG, n = 33). All participants received standard antivenom therapy, with CTG and HTG receiving additional interventions applied for 24 hours post-admission. Primary outcomes included changes in creatine kinase (CK) levels. Secondary outcomes assessed pain intensity, edema, local temperature, and functional recovery using the World Health Organization Disability As","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-04-08T05:07:00.135Z","creation":"2026-04-07T22:20:46.99Z"},"accession":"S-EPMC12367189","cross_references":{"pubmed":["40811728"],"doi":["10.1371/journal.pntd.0013423"]}}