{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2025"],"submitter":["Li X"],"pubmed_abstract":["Diabetic retinopathy (DR), a leading cause of vision impairment worldwide, is characterized by early neuronal damage in the retina, termed diabetic neuropathy in the retina (DNR). This condition is marked by neuronal apoptosis and glial activation. Müller glia are retinal cells highly susceptible to diabetic metabolic stress that may undergo ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation. However, the role of ferroptosis in DNR pathogenesis remains undefined. In this study, we investigated Müller cell injury under high-glucose and palmitic acid (HGP) conditions. The retinal tissues were obtained from normal rabbits and alloxan-induced diabetic rabbits. HGP exposure significantly reduced Müller cell viability, induced cell cycle arrest, and elevated"],"journal":["Journal of diabetes research"],"pagination":["1924668"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12367365"],"repository":["biostudies-literature"],"pubmed_title":["Upregulation of SQSTM1 Regulates Ferroptosis and Oxidative Stress in Muller Cells of the Diabetic Neural Retina by Modulating ACSL4."],"pmcid":["PMC12367365"],"pubmed_authors":["Li X","Yang J","Dong X","Mei Y","Hu H","Jiang H","Tang B","Feng D","Li B","Ni N","Li L"],"additional_accession":[]},"is_claimable":false,"name":"Upregulation of SQSTM1 Regulates Ferroptosis and Oxidative Stress in Muller Cells of the Diabetic Neural Retina by Modulating ACSL4.","description":"Diabetic retinopathy (DR), a leading cause of vision impairment worldwide, is characterized by early neuronal damage in the retina, termed diabetic neuropathy in the retina (DNR). This condition is marked by neuronal apoptosis and glial activation. Müller glia are retinal cells highly susceptible to diabetic metabolic stress that may undergo ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation. However, the role of ferroptosis in DNR pathogenesis remains undefined. In this study, we investigated Müller cell injury under high-glucose and palmitic acid (HGP) conditions. The retinal tissues were obtained from normal rabbits and alloxan-induced diabetic rabbits. HGP exposure significantly reduced Müller cell viability, induced cell cycle arrest, and elevated","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-04-08T15:37:36.095Z","creation":"2026-04-08T05:09:42.347Z"},"accession":"S-EPMC12367365","cross_references":{"pubmed":["40843317"],"doi":["10.1155/jdr/1924668"]}}