biostudies-literatureUnknown16Wang XThis study aimed to explore the differences in symptom clusters of adenomyosis (AM) patients across spatial, temporal, and age-stratified dimensions based on the theory of "Treatment in Accordance with Three Categories of Etiologic Factors". A cross-sectional study was conducted in China from 2020 to 2022, involving 1,816 AM patients. Univariate analysis, symptom co-occurrence matrices, and hierarchical clustering were used to compare clinical and symptom cluster characteristics across different latitudes (low latitude area: 691 cases vs. high latitude area: 1,125 cases), seasons (warm: 652 cases vs. cold: 473 cases), and age groups (<40 years: 895 cases vs. ≥s. years: 921 cases). AM symptom clusters exhibited significant geographical, seasonal, and age-related variations, with "Blood StasFrontiers in endocrinology1605310https://www.ebi.ac.uk/biostudies/studies/S-EPMC12367498biostudies-literatureSpatial, temporal and demographic distribution characteristics of adenomyosis symptom clusters from the perspective of traditional Chinese medicine: a multicenter cross-sectional study in China from 2020 to 2022.PMC12367498Yang XZhao RTao YFu YWang XfalseSpatial, temporal and demographic distribution characteristics of adenomyosis symptom clusters from the perspective of traditional Chinese medicine: a multicenter cross-sectional study in China from 2020 to 2022.This study aimed to explore the differences in symptom clusters of adenomyosis (AM) patients across spatial, temporal, and age-stratified dimensions based on the theory of "Treatment in Accordance with Three Categories of Etiologic Factors". A cross-sectional study was conducted in China from 2020 to 2022, involving 1,816 AM patients. Univariate analysis, symptom co-occurrence matrices, and hierarchical clustering were used to compare clinical and symptom cluster characteristics across different latitudes (low latitude area: 691 cases vs. high latitude area: 1,125 cases), seasons (warm: 652 cases vs. cold: 473 cases), and age groups (<40 years: 895 cases vs. ≥s. years: 921 cases). AM symptom clusters exhibited significant geographical, seasonal, and age-related variations, with "Blood Stas2025-01-01T00:00:00Z20252026-04-08T08:23:19.482Z2026-04-08T00:17:13.006ZS-EPMC123674984085218510.3389/fendo.2025.1605310