{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Assary E"],"funding":["European Research Council","NIA NIH HHS","EPA","NIMH NIH HHS","Dutch Research Council (NWO)","NIAAA NIH HHS","Wellcome Trust"],"pagination":["1683-1696"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12367547"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(8)"],"pubmed_abstract":["Individual sensitivity to environmental exposures may be genetically influenced. This genotype-by-environment interplay implies differences in phenotypic variance across genotypes, but these variants have proven challenging to detect. Genome-wide association studies of monozygotic twin differences are conducted through family-based variance analyses, which are more robust to the systemic biases that impact population-based methods. We combined data from 21,792 monozygotic twins (10,896 pairs) from 11 studies to conduct one of the largest genome-wide association study meta-analyses of monozygotic phenotypic differences, in children, adolescents and adults separately, for seven psychiatric and neurodevelopmental phenotypes: attention deficit hyperactivity disorder symptoms, autistic traits, "],"journal":["Nature human behaviour"],"pubmed_title":["Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes."],"pmcid":["PMC12367547"],"funding_grant_id":["P01 AG008761","R01 AG059329","K05 AA000145","R01 AA009203","R01 AG008724","208881/Z/17/Z","R01 AG037985","R01 AA015416","208806/Z/17/Z","R01 AA012502","R01 AG050595","R01 AG017561","R01 AG010175","R37 AA012502","R01 MH130448","R01 AG060470","R01 AG046938","EP-C-15-001","480-15-001","771057","K02 AA018755","R01 AG028555"],"pubmed_authors":["Palviainen T","Thalamuthu A","Trollor JN","Cheesman R","Armstrong NJ","Reynolds CA","Kaprio J","Havdahl A","Ames D","Martin NG","Coleman JRI","Wright M","de Geus E","Gordon S","Ask H","Larsson H","Plomin R","Paige Harden K","Taylor M","Medland SE","Chen Z","Magnus P","Hammond CJ","Latvala A","Hemani G","Nygaard M","Ordonana JR","Walters RG","Bartels M","Howe LJ","Colodro-Conde L","Li L","Evans D","Assary E","Vuoksimaa E","Li S","Akingbuwa W","Archie C","Grasby KL","Mengel-From J","Catts VS","Lin K","Benjamin DJ","Keller MC","Christensen K","van de Weijer MP","Oskarsson S","Sachdev PS","Millwood IY","Pyun H","Torvik FA","Willoughby EA","Mallard T","Munroe PB","Keers R","Within Family Consortium","Morris S","Madrid-Valero JJ","Boivin M","Eley TC","Hughes AM","Pedersen NL","Brodaty H","Brescianini S","Hottenga JJ","Tucker-Drob EM","Sung J","Lee SJ","Lichtenstein P","Boomsma DI","Pingault JB","Davies NM","Lundstrom S","Huider F","Mather KA","Ahlskog R","Giannelis A","Asvold BO","Lim K","Hill WD","Lee T","Karlsson R"],"additional_accession":[]},"is_claimable":false,"name":"Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes.","description":"Individual sensitivity to environmental exposures may be genetically influenced. This genotype-by-environment interplay implies differences in phenotypic variance across genotypes, but these variants have proven challenging to detect. Genome-wide association studies of monozygotic twin differences are conducted through family-based variance analyses, which are more robust to the systemic biases that impact population-based methods. We combined data from 21,792 monozygotic twins (10,896 pairs) from 11 studies to conduct one of the largest genome-wide association study meta-analyses of monozygotic phenotypic differences, in children, adolescents and adults separately, for seven psychiatric and neurodevelopmental phenotypes: attention deficit hyperactivity disorder symptoms, autistic traits, ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-29T17:17:03.355Z","creation":"2026-04-08T05:25:06.844Z"},"accession":"S-EPMC12367547","cross_references":{"pubmed":["40494901"],"doi":["10.1038/s41562-025-02193-7"]}}