biostudies-literatureUnknown16Shen LAutoimmune diseases have different pathogenic mechanisms but share underlying patterns of gut microbiome perturbation and intestinal barrier dysfunction. Recent evidence suggests that an arthritogenic strain of Subdoligranulum causes a local inflammatory response in the gut. Therefore, the aim of this review was to systematically summarize the relationships between Subdoligranulum and multiple autoimmune diseases. To evaluate the changes of Subdoligranulum in different autoimmune diseases. Four databases, including PubMed, Cochrane, Web of Science, and Embase, were searched up to June 17, 2025, to identify studies that detected Subdoligranulum in autoimmune diseases. A meta-analysis was conducted to compare the differences in Subdoligranulum between healthy people and patients with autoimmFrontiers in immunology1619160https://www.ebi.ac.uk/biostudies/studies/S-EPMC12367689biostudies-literatureChanges in the <i>Subdoligranulum</i> genus in patients with autoimmune disease: a systematic review and meta-analysis.PMC12367689Shen LLi STung THLi QLiu SShen BZhao YfalseChanges in the <i>Subdoligranulum</i> genus in patients with autoimmune disease: a systematic review and meta-analysis.Autoimmune diseases have different pathogenic mechanisms but share underlying patterns of gut microbiome perturbation and intestinal barrier dysfunction. Recent evidence suggests that an arthritogenic strain of Subdoligranulum causes a local inflammatory response in the gut. Therefore, the aim of this review was to systematically summarize the relationships between Subdoligranulum and multiple autoimmune diseases. To evaluate the changes of Subdoligranulum in different autoimmune diseases. Four databases, including PubMed, Cochrane, Web of Science, and Embase, were searched up to June 17, 2025, to identify studies that detected Subdoligranulum in autoimmune diseases. A meta-analysis was conducted to compare the differences in Subdoligranulum between healthy people and patients with autoimm2025-01-01T00:00:00Z20252026-04-08T08:19:02.348Z2026-04-08T00:16:41.001ZS-EPMC123676894085270810.3389/fimmu.2025.1619160