{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(32)"],"submitter":["Thatte C"],"pubmed_abstract":["The number of disorders linked to deficiencies in vital ions, such as calcium (Ca2+) and potassium (K+), has dramatically increased in recent years. Numerous research studies have proposed the development of a sensor for early detection; however, the bulk of these investigations include the time-consuming process of drawing blood samples for testing. To overcome these challenges, this research highlights the development of a novel portable microneedle-based device for the multiplexed detection of Ca2+ and K+, as well as pH, in artificial interstitial fluid (ISF). A passivation layer of ArCare was investigated to improve the stability, reliability, and repeatability of the microneedle sensors, enhancing their sensitivity and accuracy. Microneedle sensors were modified with Poly-(3,4-ethylen"],"journal":["ACS omega"],"pagination":["36203-36215"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12368728"],"repository":["biostudies-literature"],"pubmed_title":["A Microneedle-Based Electrochemical Sensor with Multiplex Detection in Physiological Environment and Incorporated in a Portable Device."],"pmcid":["PMC12368728"],"pubmed_authors":["Thatte C","Ferreira C","Galvin P","Teixeira SR","Cioce V","O'Keeffe E","Barry F"],"additional_accession":[]},"is_claimable":false,"name":"A Microneedle-Based Electrochemical Sensor with Multiplex Detection in Physiological Environment and Incorporated in a Portable Device.","description":"The number of disorders linked to deficiencies in vital ions, such as calcium (Ca2+) and potassium (K+), has dramatically increased in recent years. Numerous research studies have proposed the development of a sensor for early detection; however, the bulk of these investigations include the time-consuming process of drawing blood samples for testing. To overcome these challenges, this research highlights the development of a novel portable microneedle-based device for the multiplexed detection of Ca2+ and K+, as well as pH, in artificial interstitial fluid (ISF). A passivation layer of ArCare was investigated to improve the stability, reliability, and repeatability of the microneedle sensors, enhancing their sensitivity and accuracy. Microneedle sensors were modified with Poly-(3,4-ethylen","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-09T00:13:34.413Z","creation":"2026-04-08T00:17:42.745Z"},"accession":"S-EPMC12368728","cross_references":{"pubmed":["40852252"],"doi":["10.1021/acsomega.5c04024"]}}