biostudies-literatureUnknownSawka AM<h4>Importance</h4>In managing early-stage cancers, active surveillance (AS) may be preferentially favored by older individuals. In counseling patients, it is important to understand the durability of AS in the context of age.<h4>Objective</h4>To evaluate the durability of AS in patients with small, low-risk papillary thyroid cancer (PTC) according to age at the time of choosing AS.<h4>Design, setting, and participants</h4>This single-center, prospective, long-term follow-up cohort study was conducted at a tertiary care hospital in Toronto, Ontario, Canada. Adult patients with small, localized, low-risk PTC less than 2 cm in maximal diameter were enrolled between May 2016 and February 2021. The clinical outcome data were analyzed up to the time point of May 25, 2025, and final data analysiJAMA surgeryhttps://www.ebi.ac.uk/biostudies/studies/S-EPMC12368792biostudies-literatureLong-Term Durability of Active Surveillance of Small, Low-Risk Papillary Thyroid Cancer.PMC12368792Shah MHiggins KHay MGooden ESu JDevon KSolomon PWitterick IJones JMGantous AHalperin IJGilbert REsemezie AOBindlish VEskander APasternak JDWhiteacre LAnand Sde Almeida JGoldstein DPLin DVescan AEnepekides DTsang RWXu WNazarali KBaxter NNRotstein LCanadian Thyroid Cancer Active Surveillance Study Group (Greater Toronto Area)Bharadwaj VIrish JCEzzat SBanerjee APrudencio JSawka AMGhai SGullane PJHafidh MSegall LKorman MFernandes VChang MMonteiro EMadani AArruda EChung JGevorgyan AGomez Hernandez KAnderson JZahedi AGafni AfalseLong-Term Durability of Active Surveillance of Small, Low-Risk Papillary Thyroid Cancer.<h4>Importance</h4>In managing early-stage cancers, active surveillance (AS) may be preferentially favored by older individuals. In counseling patients, it is important to understand the durability of AS in the context of age.<h4>Objective</h4>To evaluate the durability of AS in patients with small, low-risk papillary thyroid cancer (PTC) according to age at the time of choosing AS.<h4>Design, setting, and participants</h4>This single-center, prospective, long-term follow-up cohort study was conducted at a tertiary care hospital in Toronto, Ontario, Canada. Adult patients with small, localized, low-risk PTC less than 2 cm in maximal diameter were enrolled between May 2016 and February 2021. The clinical outcome data were analyzed up to the time point of May 25, 2025, and final data analysi2025-01-01T00:00:00Z2025 Aug2026-05-29T15:24:56.659Z2026-04-08T05:18:43.107ZS-EPMC123687924083376910.1001/jamasurg.2025.2957