{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["29"],"submitter":["Ming L"],"pubmed_abstract":["Camel milk exosomes from colostrum (C) and mature milk (M) were characterized using proteomics and lipidomics to elucidate their compositional and functional differences. Isolated exosomes exhibited round and cup-like concave spheres of 30 to 150 nm and higher TSG101 expression in colostrum. Proteomic analysis identified 2479 proteins, with 843 differentially expressed (357 upregulated, 486 downregulated) between C and M, enriched in PI3K-AKT signaling, endocytosis, and complement/coagulation pathways, suggesting roles in immune regulation and neonatal development. Lipidomics revealed 1783 lipid species (37 subclasses), with 149 significantly altered between C and M, including SM (d42:4; FC = 221.887) and LPE (18:3; FC = 0.139). Colostrum exosomes were enriched in sphingomyelins and glycer"],"journal":["Food chemistry: X"],"pagination":["102729"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12369441"],"repository":["biostudies-literature"],"pubmed_title":["A new insight into the exosome protein and lipid composition in camel colostrum and mature milk using comparative proteome and lipidomics analyses."],"pmcid":["PMC12369441"],"pubmed_authors":["Ming L","Ji R","Yi L","Ai Y"],"additional_accession":[]},"is_claimable":false,"name":"A new insight into the exosome protein and lipid composition in camel colostrum and mature milk using comparative proteome and lipidomics analyses.","description":"Camel milk exosomes from colostrum (C) and mature milk (M) were characterized using proteomics and lipidomics to elucidate their compositional and functional differences. Isolated exosomes exhibited round and cup-like concave spheres of 30 to 150 nm and higher TSG101 expression in colostrum. Proteomic analysis identified 2479 proteins, with 843 differentially expressed (357 upregulated, 486 downregulated) between C and M, enriched in PI3K-AKT signaling, endocytosis, and complement/coagulation pathways, suggesting roles in immune regulation and neonatal development. Lipidomics revealed 1783 lipid species (37 subclasses), with 149 significantly altered between C and M, including SM (d42:4; FC = 221.887) and LPE (18:3; FC = 0.139). Colostrum exosomes were enriched in sphingomyelins and glycer","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-05-29T16:54:03.558Z","creation":"2026-04-08T05:29:36.718Z"},"accession":"S-EPMC12369441","cross_references":{"pubmed":["40852571"],"doi":["10.1016/j.fochx.2025.102729"]}}