biostudies-literatureUnknown15(1)Almehizia AAThis study successfully encapsulated palladium nanoparticles within the metal-organic framework material UiO-66 using a straightforward method. Utilizing a microwave-assisted process, the pores of UiO-66 were activated, and the metal precursors were simultaneously reduced in the presence of a reducing agent. The morphological and physicochemical properties of the resulting material were thoroughly analyzed using various techniques, including EDX, SEM, XRD, TGA, BET, and ICP-OES. UiO-66-NH2-Pd demonstrated highly efficient catalytic activity in C-O cross-coupling reactions under mild conditions. Moreover, this nanostructured material offers notable advantages, such as high reaction efficiency, a simple preparation process, and environmentally friendly characteristics. The catalyst was easily recovered via centrifugation and recycled five times without significant palladium leaching or any substantial loss in activity.Scientific reports30757https://www.ebi.ac.uk/biostudies/studies/S-EPMC12371003biostudies-literatureSynthesis of an efficient MOF heterogeneous catalyst (UiO-66-NH₂-Pd) for C-O cross-coupling reactions.PMC12371003Jadeja YAbdul Kareem RKashyap AKavitha VAlmehizia AARoopashree RChou-Yi HsuRajput PRay SKumar AfalseSynthesis of an efficient MOF heterogeneous catalyst (UiO-66-NH₂-Pd) for C-O cross-coupling reactions.This study successfully encapsulated palladium nanoparticles within the metal-organic framework material UiO-66 using a straightforward method. Utilizing a microwave-assisted process, the pores of UiO-66 were activated, and the metal precursors were simultaneously reduced in the presence of a reducing agent. The morphological and physicochemical properties of the resulting material were thoroughly analyzed using various techniques, including EDX, SEM, XRD, TGA, BET, and ICP-OES. UiO-66-NH2-Pd demonstrated highly efficient catalytic activity in C-O cross-coupling reactions under mild conditions. Moreover, this nanostructured material offers notable advantages, such as high reaction efficiency, a simple preparation process, and environmentally friendly characteristics. The catalyst was easily recovered via centrifugation and recycled five times without significant palladium leaching or any substantial loss in activity.2025-01-01T00:00:00Z2025 Aug2026-05-08T10:47:54.561Z2026-04-07T23:47:38.954ZS-EPMC123710034084141510.1038/s41598-025-14717-2