biostudies-literatureUnknown30(24)Shaburishvili TA number of transcatheter-based therapies are emerging as therapeutic options for high-surgical risk patients with moderate-to-severe or severe mitral regurgitation (MR). This is the first published report of treatment with the fully percutaneous, transfemoral, transseptal Saturn mitral valve replacement device in a 66-year-old woman with 3+ symptomatic MR. Ultimately, the patient had elimination of her MR and symptomatic improvement. This transcatheter mitral valve replacement device allows for basal annular stabilization and preservation of the neo-left ventricular outflow tract. Despite the difficult anatomy (small left heart size and limited transseptal height), device implantation was successful with the Saturn delivery system. Saturn transcatheter mitral valve replacement offers a feasible alternative for the treatment of secondary MR.JACC. Case reports104739https://www.ebi.ac.uk/biostudies/studies/S-EPMC12371422biostudies-literatureTransseptal Transcatheter Mitral Valve Replacement With a Novel Bioprosthesis in a Patient With Challenging Anatomy.PMC12371422Zirakashvili TStella SVahl TPRanard LSDenti PShaburishvili TfalseTransseptal Transcatheter Mitral Valve Replacement With a Novel Bioprosthesis in a Patient With Challenging Anatomy.A number of transcatheter-based therapies are emerging as therapeutic options for high-surgical risk patients with moderate-to-severe or severe mitral regurgitation (MR). This is the first published report of treatment with the fully percutaneous, transfemoral, transseptal Saturn mitral valve replacement device in a 66-year-old woman with 3+ symptomatic MR. Ultimately, the patient had elimination of her MR and symptomatic improvement. This transcatheter mitral valve replacement device allows for basal annular stabilization and preservation of the neo-left ventricular outflow tract. Despite the difficult anatomy (small left heart size and limited transseptal height), device implantation was successful with the Saturn delivery system. Saturn transcatheter mitral valve replacement offers a feasible alternative for the treatment of secondary MR.2025-01-01T00:00:00Z2025 Aug2026-04-08T09:17:24.66Z2026-04-08T00:48:30.29ZS-EPMC123714224084636810.1016/j.jaccas.2025.104739