{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(8)"],"submitter":["Babeliowsky WA"],"pubmed_abstract":["<h4>Background</h4>The diagnosis of orthostatic tremor (OT) is challenging because of its non-specific symptoms and a broad range of differential diagnosis, resulting in a complex and lengthy diagnostic journey.<h4>Objective</h4>The aim was to assess the diagnostic delay in OT and to identify key clinical indicators as reported by patients.<h4>Methods</h4>In 2019, the American OT community developed and distributed a web-based survey titled \"Symptoms and Diagnosis of Orthostatic Tremor (OT).\" The survey included questions on demographics, the diagnostic process, and symptomatology.<h4>Results</h4>An international cohort of 360 OT patients participated in the study, of which 147 with electromyography (EMG)-confirmed and 213 symptom-based OT. In the EMG-confirmed OT group, respondents reported an average diagnostic delay of 7.4 (±8.5) years on average, attributed to delays at both the patient and physician level. A diagnosis was made by a movement disorders specialist in 75 (51.0%) of 147 cases. Misdiagnosis initially occurred in 57 (38.8%) of 147 patients, whereas 49 (33.3%) of 147 patients suspected OT before receiving a formal diagnosis. OT was commonly reported a progressive condition. The most frequent symptoms on standing that prompted patients to seek medical attention included: \"shakiness/tremors in both legs\" (92.5%), \"feelings of unsteadiness or imbalance\" (75.5%), \"toe curling\" (61.9%), and the \"feeling of falling while standing\" (45.6%). Notably, 70.0% of respondents reported experiencing anxiety at least occasionally. These findings closely align with the findings of the symptom-based OT group.<h4>Conclusion</h4>This study underscores a significant diagnostic delay in OT and identifies key clinical indicators, which could facilitate earlier diagnosis."],"journal":["Movement disorders clinical practice"],"pagination":["1124-1131"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12371454"],"repository":["biostudies-literature"],"pubmed_title":["Identifying the Diagnostic Challenges and Indicators of Orthostatic Tremor: Patient Perspectives."],"pmcid":["PMC12371454"],"pubmed_authors":["Woodward K","Doss S","van Rootselaar AF","Muir M","de Bie RMA","Swinnen B","Babeliowsky WA","Torres-Russotto DR"],"additional_accession":[]},"is_claimable":false,"name":"Identifying the Diagnostic Challenges and Indicators of Orthostatic Tremor: Patient Perspectives.","description":"<h4>Background</h4>The diagnosis of orthostatic tremor (OT) is challenging because of its non-specific symptoms and a broad range of differential diagnosis, resulting in a complex and lengthy diagnostic journey.<h4>Objective</h4>The aim was to assess the diagnostic delay in OT and to identify key clinical indicators as reported by patients.<h4>Methods</h4>In 2019, the American OT community developed and distributed a web-based survey titled \"Symptoms and Diagnosis of Orthostatic Tremor (OT).\" The survey included questions on demographics, the diagnostic process, and symptomatology.<h4>Results</h4>An international cohort of 360 OT patients participated in the study, of which 147 with electromyography (EMG)-confirmed and 213 symptom-based OT. In the EMG-confirmed OT group, respondents reported an average diagnostic delay of 7.4 (±8.5) years on average, attributed to delays at both the patient and physician level. A diagnosis was made by a movement disorders specialist in 75 (51.0%) of 147 cases. Misdiagnosis initially occurred in 57 (38.8%) of 147 patients, whereas 49 (33.3%) of 147 patients suspected OT before receiving a formal diagnosis. OT was commonly reported a progressive condition. The most frequent symptoms on standing that prompted patients to seek medical attention included: \"shakiness/tremors in both legs\" (92.5%), \"feelings of unsteadiness or imbalance\" (75.5%), \"toe curling\" (61.9%), and the \"feeling of falling while standing\" (45.6%). Notably, 70.0% of respondents reported experiencing anxiety at least occasionally. These findings closely align with the findings of the symptom-based OT group.<h4>Conclusion</h4>This study underscores a significant diagnostic delay in OT and identifies key clinical indicators, which could facilitate earlier diagnosis.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-08T10:53:28.265Z","creation":"2026-05-02T03:07:18.695Z"},"accession":"S-EPMC12371454","cross_references":{"pubmed":["40265716"],"doi":["10.1002/mdc3.70081"]}}