{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["64"],"submitter":["Lassen P"],"pubmed_abstract":["p16-expression are implemented in the TNM8 classification of oropharyngeal cancer (OPSCC). Based on a nationwide cohort, we provide a detailed description of subsite variation in the age-standardised incidence-rates of OPSCC alongside an evaluation of the prognostic impact of p16-expression according to subsite after primary radiotherapy (RT). Patient/material and methods: A total of 8,462 Danish OPSCC patients from 1986 to 2020 were identified in the DAHANCA-database, and tumours were grouped into 'tonsil/base of tongue (BOT)', 'neighbouring subsites' and 'distant subsites'. Subsite-specific age-standardised incidence-rates were calculated, and outcome-analysis (loco-regional control, disease-free survival and overall-survival 5 years after the completion of RT) stratified by p16-status/s"],"journal":["Acta oncologica (Stockholm, Sweden)"],"pagination":["1071-1078"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12371743"],"repository":["biostudies-literature"],"pubmed_title":["Subsite variation of HPV-related p16-expression in oropharynx cancer: Incidence and prognostic impact in a population-based DAHANCA cohort 1986-2020."],"pmcid":["PMC12371743"],"pubmed_authors":["Johansen J","Maare C","Andersen M","Primdahl H","Alsner J","Plaschke CC","Overgaard J","Lassen P","Farhadi M"],"additional_accession":[]},"is_claimable":false,"name":"Subsite variation of HPV-related p16-expression in oropharynx cancer: Incidence and prognostic impact in a population-based DAHANCA cohort 1986-2020.","description":"p16-expression are implemented in the TNM8 classification of oropharyngeal cancer (OPSCC). Based on a nationwide cohort, we provide a detailed description of subsite variation in the age-standardised incidence-rates of OPSCC alongside an evaluation of the prognostic impact of p16-expression according to subsite after primary radiotherapy (RT). Patient/material and methods: A total of 8,462 Danish OPSCC patients from 1986 to 2020 were identified in the DAHANCA-database, and tumours were grouped into 'tonsil/base of tongue (BOT)', 'neighbouring subsites' and 'distant subsites'. Subsite-specific age-standardised incidence-rates were calculated, and outcome-analysis (loco-regional control, disease-free survival and overall-survival 5 years after the completion of RT) stratified by p16-status/s","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-09T10:36:07.604Z","creation":"2026-04-08T00:47:38.661Z"},"accession":"S-EPMC12371743","cross_references":{"pubmed":["40814244"],"doi":["10.2340/1651-226X.2025.44027"]}}