{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bloch JM"],"funding":["Division of Chemistry","National Cancer Institute","National Institute of General Medical Sciences","NIGMS NIH HHS","National Institute on Aging"],"pagination":["30146-30153"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12371869"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["147(33)"],"pubmed_abstract":["The Diels-Alder reaction of benzenes remains a significant synthetic challenge, owing to their highly stabilized aromatic cores. In this work, the dearomatization agent {WTp(NO)(PMe<sub>3</sub>)} is used to promote Diels-Alder reactions of dihapto-coordinated (η<sup>2</sup>) benzenes with alkynes. The resulting η<sup>2</sup>-barrelene complexes can be oxidized to liberate intact barrelenes. Alternatively, mild pyrolysis leads to the extraction of the corresponding tungsten-acetylene complex and concomitant formation of new arenes possessing substituents originating from the acetylene dienophiles."],"journal":["Journal of the American Chemical Society"],"pubmed_title":["Tungsten-Enabled Diels-Alder Cycloaddition and Cycloreversion of Arenes and Alkynes: Divergent Synthesis of Highly Functionalized Barrelenes and Arenes."],"pmcid":["PMC12371869"],"funding_grant_id":["R21AG07699","CHE-2215062","R35 GM152065","CHE-2018870","R35GM152065","P30CA044579"],"pubmed_authors":["Bloch JM","Ericson MN","Tepe JJ","Savelson E","Meng AQ","Dickie DA","Harman WD","Patel IU"],"additional_accession":[]},"is_claimable":false,"name":"Tungsten-Enabled Diels-Alder Cycloaddition and Cycloreversion of Arenes and Alkynes: Divergent Synthesis of Highly Functionalized Barrelenes and Arenes.","description":"The Diels-Alder reaction of benzenes remains a significant synthetic challenge, owing to their highly stabilized aromatic cores. In this work, the dearomatization agent {WTp(NO)(PMe<sub>3</sub>)} is used to promote Diels-Alder reactions of dihapto-coordinated (η<sup>2</sup>) benzenes with alkynes. The resulting η<sup>2</sup>-barrelene complexes can be oxidized to liberate intact barrelenes. Alternatively, mild pyrolysis leads to the extraction of the corresponding tungsten-acetylene complex and concomitant formation of new arenes possessing substituents originating from the acetylene dienophiles.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-08T10:50:37.592Z","creation":"2026-05-03T03:05:53.924Z"},"accession":"S-EPMC12371869","cross_references":{"pubmed":["40779317"],"doi":["10.1021/jacs.5c08320"]}}