{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pun M"],"funding":["United States - Israel Binational Agricultural Research and Development Fund"],"pagination":["20792-20809"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12371876"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["73(33)"],"pubmed_abstract":["Naringenin, a flavanone from citrus, was studied for its ability to reduce virulence in <i>Pectobacterium</i>, a phytopathogen causing soft rot disease in crop plants. Naringenin downregulated quorum sensing (QS) and suppressed critical virulence determinants in <i>Pectobacterium brasiliense</i> Pb1692, including plant cell wall-degrading enzymes, bacterial motility, and biofilm formation, consequently reducing disease symptoms in two host plants. Molecular docking simulations revealed a plausible binding mode for naringenin within the QS protein ExpI, which were maintained during microsecond-long Molecular Dynamics simulations. These simulations provided atomic-scale insight into specific interactions and estimated binding free energies, supporting naringenin's QS inhibition mode of actio"],"journal":["Journal of agricultural and food chemistry"],"pubmed_title":["Multimodal Inhibition of &lt;i&gt;Pectobacterium brasiliense&lt;/i&gt; Virulence by the Citrus Flavanone Naringenin."],"pmcid":["PMC12371876"],"funding_grant_id":["IS-5502-22C"],"pubmed_authors":["Senderowitz H","Galsurker O","Pun M","Charkowski A","Kerem Z","Weitman M","Khazanov N","Yedidia I","Yelin S"],"additional_accession":[]},"is_claimable":false,"name":"Multimodal Inhibition of &lt;i&gt;Pectobacterium brasiliense&lt;/i&gt; Virulence by the Citrus Flavanone Naringenin.","description":"Naringenin, a flavanone from citrus, was studied for its ability to reduce virulence in <i>Pectobacterium</i>, a phytopathogen causing soft rot disease in crop plants. Naringenin downregulated quorum sensing (QS) and suppressed critical virulence determinants in <i>Pectobacterium brasiliense</i> Pb1692, including plant cell wall-degrading enzymes, bacterial motility, and biofilm formation, consequently reducing disease symptoms in two host plants. Molecular docking simulations revealed a plausible binding mode for naringenin within the QS protein ExpI, which were maintained during microsecond-long Molecular Dynamics simulations. These simulations provided atomic-scale insight into specific interactions and estimated binding free energies, supporting naringenin's QS inhibition mode of actio","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-09T10:38:50.432Z","creation":"2026-04-08T00:47:49.212Z"},"accession":"S-EPMC12371876","cross_references":{"pubmed":["40767039"],"doi":["10.1021/acs.jafc.5c04312"]}}