{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Di Agostino S"],"funding":["Ministero dell'Università e della Ricerca","Ministero dell'Università e della Ricerca","NextGenerationEU"],"pagination":["247"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12372361"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["44(1)"],"pubmed_abstract":["The tumor microenvironment (TME) plays a pivotal role in the development and progression of colorectal cancer (CRC), yet the complex crosstalk among its components remains incompletely understood. Cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs) have emerged as key regulators of CRC progression, but their specific contributions, particularly given their heterogeneity, are not fully elucidated. This study identifies podoplanin (PDPN), a transmembrane glycoprotein enriched in CAFs, as highly expressed in the CRC TME, in particular surrounding the tumor, and associated with macrophage infiltration and cancer progression. We performed mass spectrometry-based proteomic analysis on matched CRC and adjacent normal tissues from patients to identify altered signaling pat"],"journal":["Journal of experimental & clinical cancer research : CR"],"pubmed_title":["Proteomic profiling identifies a stromal TGF-β1/podoplanin axis as a driver of colorectal cancer progression."],"pmcid":["PMC12372361"],"funding_grant_id":["2022CMTZNH"],"pubmed_authors":["Curro G","Cuda G","Di Agostino S","Ranieri G","Ammendola M","Aprigliano E","Urlandini L","Conforti F","Gaspari M","Zuccala V","Ieni A","La Padula D","Abbonante V","Cernaro V","Gabriele C","Vescio F","Sacconi A","Parrotta E","Lofaro D","Rago V","Alibrandi A"],"additional_accession":[]},"is_claimable":false,"name":"Proteomic profiling identifies a stromal TGF-β1/podoplanin axis as a driver of colorectal cancer progression.","description":"The tumor microenvironment (TME) plays a pivotal role in the development and progression of colorectal cancer (CRC), yet the complex crosstalk among its components remains incompletely understood. Cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs) have emerged as key regulators of CRC progression, but their specific contributions, particularly given their heterogeneity, are not fully elucidated. This study identifies podoplanin (PDPN), a transmembrane glycoprotein enriched in CAFs, as highly expressed in the CRC TME, in particular surrounding the tumor, and associated with macrophage infiltration and cancer progression. We performed mass spectrometry-based proteomic analysis on matched CRC and adjacent normal tissues from patients to identify altered signaling pat","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-08T10:48:02.042Z","creation":"2026-04-07T23:47:44.08Z"},"accession":"S-EPMC12372361","cross_references":{"pubmed":["40842027"],"doi":["10.1186/s13046-025-03496-3"]}}