{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Allen ME"],"funding":["UK Research and Innovation","Wellcome Trust","Biotechnology and Biological Sciences Research Council"],"pagination":["e2411220"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12372441"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(33)"],"pubmed_abstract":["Stimuli-responsive polymeric vesicles offer a versatile platform for mimicking dynamic cell-like behaviors for synthetic cell applications. In this study, thermally responsive polymeric droplets derived from poly(ethylene oxide)-poly(butylene oxide) (PEO-PBO) polymersomes, aiming to create synthetic cell models that mimic key biological functions are developed. Upon heating, the nanoscale vesicles undergo fusion, transforming into sponge-like microscale droplets enriched with membrane features. By modulating the temperature, these droplets display dynamic properties such as contractility, temperature-induced fusion, and cargo trapping, including small molecules and bacteria, thereby demonstrating their ability to dynamically interface with biological entities. The findings demonstrate the potential of our sponge-like droplets in synthetic cell applications, contributing to the understanding of PEO-PBO polymersomes' unique characteristics, expanding the capabilities of synthetic cell structures, and representing an exciting possibility for advancing soft matter engineering to cell-like behaviors."],"journal":["Small (Weinheim an der Bergstrasse, Germany)"],"pubmed_title":["Thermally Driven Dynamic Behaviors in Polymeric Vesicles."],"pmcid":["PMC12372441"],"funding_grant_id":["MR/S031537/1","BB/W009323/1","RSRO_67869"],"pubmed_authors":["Paez-Perez M","Contini C","Allen ME","Chan CL","Sun Y","Elani Y","Ces O"],"additional_accession":[]},"is_claimable":false,"name":"Thermally Driven Dynamic Behaviors in Polymeric Vesicles.","description":"Stimuli-responsive polymeric vesicles offer a versatile platform for mimicking dynamic cell-like behaviors for synthetic cell applications. In this study, thermally responsive polymeric droplets derived from poly(ethylene oxide)-poly(butylene oxide) (PEO-PBO) polymersomes, aiming to create synthetic cell models that mimic key biological functions are developed. Upon heating, the nanoscale vesicles undergo fusion, transforming into sponge-like microscale droplets enriched with membrane features. By modulating the temperature, these droplets display dynamic properties such as contractility, temperature-induced fusion, and cargo trapping, including small molecules and bacteria, thereby demonstrating their ability to dynamically interface with biological entities. The findings demonstrate the potential of our sponge-like droplets in synthetic cell applications, contributing to the understanding of PEO-PBO polymersomes' unique characteristics, expanding the capabilities of synthetic cell structures, and representing an exciting possibility for advancing soft matter engineering to cell-like behaviors.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-09T10:39:36.63Z","creation":"2026-04-08T00:48:17.529Z"},"accession":"S-EPMC12372441","cross_references":{"pubmed":["40042428"],"doi":["10.1002/smll.202411220"]}}