{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20(8)"],"submitter":["Sumi S"],"pubmed_abstract":["To investigate whether corneal biomechanical parameters measured via Corvis ST can predict acute intraocular pressure (IOP) elevation following intravitreal anti-VEGF injection. Retrospective observational study. Forty eyes from patients with neovascular age-related macular degeneration or retinal vein occlusion who underwent anti-VEGF therapy. IOP was measured using the Corvis ST immediately before and 10 minutes after injection. The following biomechanical parameters were evaluated: DA Ratio MAX (2mm), biomechanically corrected IOP (bIOP), Peak Distance, Deflection Amplitude Max, Integrated Radius, and Stress-Strain Index (SSI). Acute post-injection IOP elevation (continuous) and IOP spikes ≥10 mmHg (binary). The mean IOP increased significantly from 14.5 ± 3.17 to 24.7 ± 7.44 mmHg post-injection (p < 0.0001). IOP spikes ≥10 mmHg occurred in 55% of eyes. On multivariate analysis, higher bIOP (β = +1.17, p = 0.048) and lower DA Ratio MAX (β = -5.40, p = 0.038) were independent predictors of IOP elevation. DA Ratio MAX was the only significant predictor of IOP spikes (OR = 0.70, 95% CI: 0.51-0.96, p = 0.035). ROC analysis showed that DA Ratio MAX alone (AUC = 0.739) outperformed bIOP (AUC = 0.607), with the combined model yielding the highest AUC (0.773). A cutoff of DA Ratio MAX ≤4.936 provided 81.8% sensitivity and 42.9% specificity for predicting spikes. DA Ratio MAX (2mm), reflecting global ocular compliance, was a significant predictor of acute IOP spikes after anti-VEGF injection. Alongside bIOP, it may be useful for pre-injection risk stratification of pressure-related complications."],"journal":["PloS one"],"pagination":["e0330574"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12373209"],"repository":["biostudies-literature"],"pubmed_title":["Corneal biomechanical predictors of intraocular pressure elevation after intravitreal anti-VEGF injection."],"pmcid":["PMC12373209"],"pubmed_authors":["Inoue T","Azuma K","Asaoka R","Aoki S","Sumi S","Terao R","Kawata M","Obata R","Kitamoto K"],"additional_accession":[]},"is_claimable":false,"name":"Corneal biomechanical predictors of intraocular pressure elevation after intravitreal anti-VEGF injection.","description":"To investigate whether corneal biomechanical parameters measured via Corvis ST can predict acute intraocular pressure (IOP) elevation following intravitreal anti-VEGF injection. Retrospective observational study. Forty eyes from patients with neovascular age-related macular degeneration or retinal vein occlusion who underwent anti-VEGF therapy. IOP was measured using the Corvis ST immediately before and 10 minutes after injection. The following biomechanical parameters were evaluated: DA Ratio MAX (2mm), biomechanically corrected IOP (bIOP), Peak Distance, Deflection Amplitude Max, Integrated Radius, and Stress-Strain Index (SSI). Acute post-injection IOP elevation (continuous) and IOP spikes ≥10 mmHg (binary). The mean IOP increased significantly from 14.5 ± 3.17 to 24.7 ± 7.44 mmHg post-injection (p < 0.0001). IOP spikes ≥10 mmHg occurred in 55% of eyes. On multivariate analysis, higher bIOP (β = +1.17, p = 0.048) and lower DA Ratio MAX (β = -5.40, p = 0.038) were independent predictors of IOP elevation. DA Ratio MAX was the only significant predictor of IOP spikes (OR = 0.70, 95% CI: 0.51-0.96, p = 0.035). ROC analysis showed that DA Ratio MAX alone (AUC = 0.739) outperformed bIOP (AUC = 0.607), with the combined model yielding the highest AUC (0.773). A cutoff of DA Ratio MAX ≤4.936 provided 81.8% sensitivity and 42.9% specificity for predicting spikes. DA Ratio MAX (2mm), reflecting global ocular compliance, was a significant predictor of acute IOP spikes after anti-VEGF injection. Alongside bIOP, it may be useful for pre-injection risk stratification of pressure-related complications.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-05-08T10:46:05.131Z","creation":"2026-04-07T23:47:18.336Z"},"accession":"S-EPMC12373209","cross_references":{"pubmed":["40845040"],"doi":["10.1371/journal.pone.0330574"]}}