{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lin Z"],"funding":["Swiss National Science Foundation","European Research Council"],"pagination":["1071-1078"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12373504"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(8)"],"pubmed_abstract":["Communication between wireless field receivers and biological sensors remains a key constraint in the development of wireless electronic devices for minimally invasive medical monitoring and biomedical applications involving gene and cell therapies. Here we describe a nanoparticle-cell interface that enables electromagnetic programming of wireless expression regulation (EMPOWER) of transgenes via the generation of cellular reactive oxygen species (ROS) at a biosafe level. Multiferroic nanoparticles coated with chitosan to improve biocompatibility generate ROS in the cytoplasm of cells in response to a low-frequency (1-kHz) magnetic field. Overexpressed ROS-responsive KEAP1/NRF2 biosensors detect the generated ROS which is rewired to synthetic ROS-responsive promoters to drive transgene expression. In a proof-of-concept study, subcutaneously implanted alginate-microencapsulated cells stably expressing an EMPOWER-controlled insulin expression system normalized blood-glucose levels in a mouse model of type 1 diabetes in response to a weak magnetic field."],"journal":["Nature nanotechnology"],"pubmed_title":["Electromagnetic wireless remote control of mammalian transgene expression."],"pmcid":["PMC12373504"],"funding_grant_id":["ElectroGene 785800","785800","NCCR Molecular Systems Engineering"],"pubmed_authors":["Buchmann P","Fussenegger M","Huang J","Guha Ray P","Lin Z"],"additional_accession":[]},"is_claimable":false,"name":"Electromagnetic wireless remote control of mammalian transgene expression.","description":"Communication between wireless field receivers and biological sensors remains a key constraint in the development of wireless electronic devices for minimally invasive medical monitoring and biomedical applications involving gene and cell therapies. Here we describe a nanoparticle-cell interface that enables electromagnetic programming of wireless expression regulation (EMPOWER) of transgenes via the generation of cellular reactive oxygen species (ROS) at a biosafe level. Multiferroic nanoparticles coated with chitosan to improve biocompatibility generate ROS in the cytoplasm of cells in response to a low-frequency (1-kHz) magnetic field. Overexpressed ROS-responsive KEAP1/NRF2 biosensors detect the generated ROS which is rewired to synthetic ROS-responsive promoters to drive transgene expression. In a proof-of-concept study, subcutaneously implanted alginate-microencapsulated cells stably expressing an EMPOWER-controlled insulin expression system normalized blood-glucose levels in a mouse model of type 1 diabetes in response to a weak magnetic field.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-08T06:54:13.1Z","creation":"2026-04-07T23:31:39.827Z"},"accession":"S-EPMC12373504","cross_references":{"pubmed":["40325210"],"doi":["10.1038/s41565-025-01929-w"]}}