{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tolba AH"],"funding":["Ministerstvo Školství, Mládeže a Tělovýchovy (Ministry of Education, Youth and Sports)"],"pagination":["7851"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12373787"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["In recent years, the catalytic activity of scandium triflate Sc(OTf)3 has attracted significant attention due to its robust Lewis acidity and the oxophilicity of Sc3+. These features have led to impressive progress in developing diverse organic reactions, including C-C bond formation. The Sc3+ also facilitates single electron transfer in photoinduced reactions either by coordination to an organophotoredox catalyst, which modifies its redox reactivity, or by the formation of a scandium-superoxide anion complex after electron transfer from a light-absorbing redox-active compound. The prior consideration of Sc3+ as a redox-inactive/innocent metal ion initially hampered the investigation of the possibility of using Sc(OTf)3 as a sole visible light photoredox catalyst. This work demonstrates the use of Sc(OTf)3 as a visible light photocatalyst capable of direct and mild aerobic oxidative C-H functionalisation of aromatic substrates by oxidation of the benzylic position and direct cyanation of the aromatic ring."],"journal":["Nature communications"],"pubmed_title":["Redox-innocent scandium(III) as the sole catalyst in visible light photooxidations."],"pmcid":["PMC12373787"],"funding_grant_id":["CZ.02.01.01/00/22_008/0004617","INFRA CZ project (ID:90254)"],"pubmed_authors":["Khan JI","Sturala J","El-Zohry AM","Tolba AH","Cibulka R","Pizl M","Svobodova E","Luspai K","Chudoba J","Klima J"],"additional_accession":[]},"is_claimable":false,"name":"Redox-innocent scandium(III) as the sole catalyst in visible light photooxidations.","description":"In recent years, the catalytic activity of scandium triflate Sc(OTf)3 has attracted significant attention due to its robust Lewis acidity and the oxophilicity of Sc3+. These features have led to impressive progress in developing diverse organic reactions, including C-C bond formation. The Sc3+ also facilitates single electron transfer in photoinduced reactions either by coordination to an organophotoredox catalyst, which modifies its redox reactivity, or by the formation of a scandium-superoxide anion complex after electron transfer from a light-absorbing redox-active compound. The prior consideration of Sc3+ as a redox-inactive/innocent metal ion initially hampered the investigation of the possibility of using Sc(OTf)3 as a sole visible light photoredox catalyst. This work demonstrates the use of Sc(OTf)3 as a visible light photocatalyst capable of direct and mild aerobic oxidative C-H functionalisation of aromatic substrates by oxidation of the benzylic position and direct cyanation of the aromatic ring.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-08T06:51:27.764Z","creation":"2026-04-07T23:31:06.16Z"},"accession":"S-EPMC12373787","cross_references":{"pubmed":["40846847"],"doi":["10.1038/s41467-025-63233-4"]}}