{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["de Morais Valentim JMB"],"funding":["Fundação Parque Tecnológico Itaipu","Conselho Nacional de Desenvolvimento Científico e Tecnológico","Secretário de Ciência, Tecnologia e Ensino Superior, Governo do Estado de Parana"],"pagination":["30910"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12373925"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Rural women are at a higher risk of developing breast cancer, but the molecular mechanisms involved remain poorly understood. This study investigates the impact of chronic pesticide exposure on systemic and tissue-level protein expressions in women diagnosed with breast cancer. Plasma and tumor samples were collected from 215 women diagnosed with breast cancer; among them, 128 patients were occupationally exposed (n = 128) and 87 patients were not occupationally exposed (87) were analyzed for further studies. High-throughput proteomic analyses of plasma revealed distinct protein expression profiles between the groups, primarily associated with inflammation, oxidative stress, and immune deregulation. Validation analysis showed that cytokines such as IL-1β, IL-12, IL-17A, and TNF-α were sign"],"journal":["Scientific reports"],"pubmed_title":["Pesticide exposome reveals oxidative stress and immune response disruptions in occupationally exposed women with breast cancer."],"pmcid":["PMC12373925"],"funding_grant_id":["4500007500/2024","220/2024","402364/2021-0, 441017/2023-1, and 305335/2021-9"],"pubmed_authors":["Pizzatti L","Kern R","Silveira GF","Dos Santos MLF","Bordignon J","Seiva FRF","de Morais Valentim JMB","Foti L","Pavanelli WR","Panis C","Coradi C","Iago Oliveira Coletto M","Rech D","Fadel B","Vacario BGL","Cristina Cazagranda I","Gaboardi SC","Cataneo AHD"],"additional_accession":[]},"is_claimable":false,"name":"Pesticide exposome reveals oxidative stress and immune response disruptions in occupationally exposed women with breast cancer.","description":"Rural women are at a higher risk of developing breast cancer, but the molecular mechanisms involved remain poorly understood. This study investigates the impact of chronic pesticide exposure on systemic and tissue-level protein expressions in women diagnosed with breast cancer. Plasma and tumor samples were collected from 215 women diagnosed with breast cancer; among them, 128 patients were occupationally exposed (n = 128) and 87 patients were not occupationally exposed (87) were analyzed for further studies. High-throughput proteomic analyses of plasma revealed distinct protein expression profiles between the groups, primarily associated with inflammation, oxidative stress, and immune deregulation. Validation analysis showed that cytokines such as IL-1β, IL-12, IL-17A, and TNF-α were sign","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-04-08T09:14:31.781Z","creation":"2026-04-08T00:48:07.5Z"},"accession":"S-EPMC12373925","cross_references":{"pubmed":["40846719"],"doi":["10.1038/s41598-025-12870-2"]}}