{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["21(11)"],"submitter":["Yuan Y"],"pubmed_abstract":["Long non-coding RNAs (lncRNAs) have emerged as key regulators of cancer progression through their interaction with microRNAs and modulation of gene expression. However, their role in mitochondrial metabolism, particularly in non-small cell lung cancer (NSCLC), remains poorly defined. In this study, we found that LINC02802 was significantly upregulated in NSCLC tissues and associated with poor prognosis. Mechanistically, LINC02802 acts as a competing endogenous RNA (ceRNA) for miR-1976, thereby relieving the suppression of solute carrier family 25 member 51(SLC25A51). Elevated SLC25A51 enhances mitochondrial NAD<sup>+</sup> import, leading to an increased NAD<sup>+</sup>/NADH ratio and promoting oxidative TCA cycle flux. Functionally, this shift supports tumor cell proliferation and migrati"],"journal":["International journal of biological sciences"],"pagination":["4908-4926"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12374817"],"repository":["biostudies-literature"],"pubmed_title":["N4-acetylcytidine modification of LINC02802 promotes non-small cell lung cancer progression by modulating mitochondrial NAD+/NADH ratio."],"pmcid":["PMC12374817"],"pubmed_authors":["Duan L","Zhang D","Tang L","Jiang X","Wang J","Yuan Y","Duan Y"],"additional_accession":[]},"is_claimable":false,"name":"N4-acetylcytidine modification of LINC02802 promotes non-small cell lung cancer progression by modulating mitochondrial NAD+/NADH ratio.","description":"Long non-coding RNAs (lncRNAs) have emerged as key regulators of cancer progression through their interaction with microRNAs and modulation of gene expression. However, their role in mitochondrial metabolism, particularly in non-small cell lung cancer (NSCLC), remains poorly defined. In this study, we found that LINC02802 was significantly upregulated in NSCLC tissues and associated with poor prognosis. Mechanistically, LINC02802 acts as a competing endogenous RNA (ceRNA) for miR-1976, thereby relieving the suppression of solute carrier family 25 member 51(SLC25A51). Elevated SLC25A51 enhances mitochondrial NAD<sup>+</sup> import, leading to an increased NAD<sup>+</sup>/NADH ratio and promoting oxidative TCA cycle flux. Functionally, this shift supports tumor cell proliferation and migrati","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-07-15T09:48:19.477Z","creation":"2026-07-02T03:11:52.776Z"},"accession":"S-EPMC12374817","cross_references":{"pubmed":["40860186"],"doi":["10.7150/ijbs.116639"]}}