{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Posthumus AM"],"funding":["Chiesi Pharmaceuticals BV","DSM, Animal Nutrition and Health","Ministerie van Economische Zaken en Klimaat","Astellas Pharma, Netherlands"],"pagination":["969-979"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12374880"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["40(8)"],"pubmed_abstract":["The TransplantLines Biobank and Cohort Study (NCT03272841) is an ongoing prospective study conducted at the University Medical Centre Groningen, The Netherlands. TransplantLines aims to identify risk factors and biomarkers associated with health problems following solid organ transplantation and donation. Additionally, the study seeks to develop new interventions to reduce symptom burden and improve long-term outcomes, including health-related quality of life, cardiovascular complications, graft failure, and mortality. It includes recipients of (combined) heart, liver, lung, kidney, pancreas, and small bowel transplants, as well as living liver and kidney donors, and deceased (multi-)organ donors. The biobank contains a wide range of biomaterials including whole blood, serum, EDTA-plasma, buffy coat, 24-h urine samples, faeces, hair, nails, and tissues. Data collection includes physical and cognitive assessments, extensive laboratory analysis, metagenomic sequencing, and questionnaires. TransplantLines, initiated in 2015, consists of 5143 participants as of October 2024, among 2312 (45%) females. The mean age was 50 (± 16) years at transplantation, 55 (± 11) years at living donation and 56 (± 15) years at deceased donation. Both cross-sectional and longitudinal biomaterials and data are included. For recipients, longitudinal biomaterials and data were collected at: pre-transplantation, at transplantation, and at 3, 6, 12, 24, and 60 months post-transplantation. For living donors, data were collected at pre-donation, donation, 3 months post-donation, and/or 5 or 10 years post-donation."],"journal":["European journal of epidemiology"],"pubmed_title":["TransplantLines, a biobank and cohort study of solid organ transplant recipients and donors."],"pmcid":["PMC12374880"],"funding_grant_id":["PA-SP/PRJ-2020-9136","project code: 14939","PPP-2022-015","Cohort study","project code: PPP-2019-032","TransplantLines Biobank"],"pubmed_authors":["Doorenbos CSE","TransplantLines Investigators","Dielwart IJC","Lexmond WS","Swarte JC","Bakker SJL","Kremer D","Nieuwenhuis LM","Hepkema BG","Jonker J","Velde-Keyzer CA","Blokzijl H","de Boer MT","Berger SP","Vos MJ","Pol RA","van den Heuvel MC","Gomes-Neto AW","Touw DJ","Slart RJHJA","van Pelt LJ","Leuvenink HGD","Douwes RM","Eisenga MF","Nieuwenhuis-Moeke GJ","de Borst MH","Siebelink MJ","Erasmus ME","Verschuuren EAM","de Meijer VE","van Leer-Buter C","Niesters HGM","Sanders JSF","Posthumus AM","Ranchor AV","Annema C","Gan CT","Damman K","Weersma RK","Knobbe TJ","Bodewes FAJA","Hak E","Klont F","van Londen M","Diepstra A","Dijkstra G"],"additional_accession":[]},"is_claimable":false,"name":"TransplantLines, a biobank and cohort study of solid organ transplant recipients and donors.","description":"The TransplantLines Biobank and Cohort Study (NCT03272841) is an ongoing prospective study conducted at the University Medical Centre Groningen, The Netherlands. TransplantLines aims to identify risk factors and biomarkers associated with health problems following solid organ transplantation and donation. Additionally, the study seeks to develop new interventions to reduce symptom burden and improve long-term outcomes, including health-related quality of life, cardiovascular complications, graft failure, and mortality. It includes recipients of (combined) heart, liver, lung, kidney, pancreas, and small bowel transplants, as well as living liver and kidney donors, and deceased (multi-)organ donors. The biobank contains a wide range of biomaterials including whole blood, serum, EDTA-plasma, buffy coat, 24-h urine samples, faeces, hair, nails, and tissues. Data collection includes physical and cognitive assessments, extensive laboratory analysis, metagenomic sequencing, and questionnaires. TransplantLines, initiated in 2015, consists of 5143 participants as of October 2024, among 2312 (45%) females. The mean age was 50 (± 16) years at transplantation, 55 (± 11) years at living donation and 56 (± 15) years at deceased donation. Both cross-sectional and longitudinal biomaterials and data are included. For recipients, longitudinal biomaterials and data were collected at: pre-transplantation, at transplantation, and at 3, 6, 12, 24, and 60 months post-transplantation. For living donors, data were collected at pre-donation, donation, 3 months post-donation, and/or 5 or 10 years post-donation.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-08T06:53:52.095Z","creation":"2026-04-07T23:31:33.096Z"},"accession":"S-EPMC12374880","cross_references":{"pubmed":["40601244"],"doi":["10.1007/s10654-025-01258-1"]}}