{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ji J"],"funding":["Fundamental Research Funds for the Central Universities","Start-Up Funds of Introduced Talent in Lanzhou University","National Natural Science Foundation of China","Natural Science Foundation of Gansu Province"],"pagination":["183"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12375036"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(1)"],"pubmed_abstract":["Reducing intestinal absorption by degrading purine nucleosides has been shown to alleviate hyperuricemia (HUA). The probiotic Pediococcus acidilactici GR-5, derived from the traditional food \"Jiangshui\", achieved efficient degradation of purine nucleosides through its unique purine nucleoside phosphorylase-DeoD. In the purine nucleosides-induced HUA mouse model, GR-5 treatment reduced serum uric acid (UA) by about 52.17%. GR-5 may improves tissue inflammatory damage by inhibiting the NLRP3 inflammatory pathway, and restored the intestinal barrier by increasing tight junction proteins Occludin and ZO-1 expression, which outperforming the allopurinol. The mechanism of UA reduction may also involves inhibiting UA synthase activity and regulating UA transporters level. GR-5 colonization in intestine increased the abundance of Lactobacillus, improved the metabolism of purine, tryptophan and bile acid by gut microbiota, and increased the level of SCFAs. Overall, GR-5 may be a potential preventive agent for improving HUA and is expected to provide a healthy option for preventing diet-induced HUA."],"journal":["NPJ science of food"],"pubmed_title":["Pediococcus acidilactici GR-5 alleviates hyperuricemia by degrading purine nucleosides and improving gut microbiota metabolism."],"pmcid":["PMC12375036"],"funding_grant_id":["561120220","24ZDWA005","24JRRA519","32300049","lzujbky-2023-pd11","32370110"],"pubmed_authors":["Li X","Salama ES","An ZY","Yun H","Jin WL","Liu P","Khan A","Kulshreshtha S","Ji J","Peng L"],"additional_accession":[]},"is_claimable":false,"name":"Pediococcus acidilactici GR-5 alleviates hyperuricemia by degrading purine nucleosides and improving gut microbiota metabolism.","description":"Reducing intestinal absorption by degrading purine nucleosides has been shown to alleviate hyperuricemia (HUA). The probiotic Pediococcus acidilactici GR-5, derived from the traditional food \"Jiangshui\", achieved efficient degradation of purine nucleosides through its unique purine nucleoside phosphorylase-DeoD. In the purine nucleosides-induced HUA mouse model, GR-5 treatment reduced serum uric acid (UA) by about 52.17%. GR-5 may improves tissue inflammatory damage by inhibiting the NLRP3 inflammatory pathway, and restored the intestinal barrier by increasing tight junction proteins Occludin and ZO-1 expression, which outperforming the allopurinol. The mechanism of UA reduction may also involves inhibiting UA synthase activity and regulating UA transporters level. GR-5 colonization in intestine increased the abundance of Lactobacillus, improved the metabolism of purine, tryptophan and bile acid by gut microbiota, and increased the level of SCFAs. Overall, GR-5 may be a potential preventive agent for improving HUA and is expected to provide a healthy option for preventing diet-induced HUA.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-09T17:48:54.183Z","creation":"2026-04-08T01:08:16.572Z"},"accession":"S-EPMC12375036","cross_references":{"pubmed":["40849527"],"doi":["10.1038/s41538-025-00556-y"]}}