biostudies-literatureZhang JShandong Provincial Medical and Health Technology ProgramShandong Provincial Natural Science Foundationthe National Natural Science Foundation of China31065https://www.ebi.ac.uk/biostudies/studies/S-EPMC12375064biostudies-literatureUnknown15(1)This prospective study aimed to investigate changes in corneal higher-order aberrations (HOAs) in myopic children using orthokeratology (ortho-k) lenses and their relationship with myopia progression. A total of 112 children aged 8-13 years were divided into group A (axial elongation ≤ 0.1 mm/y with ortho-k) and group B (axial elongation > 0.1 mm/y with ortho-k). At baseline, 1, 6, and 12 months following the initiation of lens wear, HOAs and corneal peripheral defocus were evaluated. Ninety-three patients completed the 1-year follow-up. The mean axial elongation was - 0.07 ± 0.15 mm/y in group A, versus 0.32 ± 0.17 mm/y in group B. No statistical differences were observed in HOAs and corneal peripheral defocus at 1, 6, and 12 months (F = 0.653, 0.878; P > 0.05). Multivariate linear regresScientific reportsCorneal higher-order aberrations as key predictive indicators of axial elongation in myopic children with orthokeratology: a single-center prospective cohort study.PMC12375064ZR2019ZD3782271052, U20A20386202307021429Ding RZhu ZZhang JZhang XWang TShi WJi YBao QfalseCorneal higher-order aberrations as key predictive indicators of axial elongation in myopic children with orthokeratology: a single-center prospective cohort study.This prospective study aimed to investigate changes in corneal higher-order aberrations (HOAs) in myopic children using orthokeratology (ortho-k) lenses and their relationship with myopia progression. A total of 112 children aged 8-13 years were divided into group A (axial elongation ≤ 0.1 mm/y with ortho-k) and group B (axial elongation > 0.1 mm/y with ortho-k). At baseline, 1, 6, and 12 months following the initiation of lens wear, HOAs and corneal peripheral defocus were evaluated. Ninety-three patients completed the 1-year follow-up. The mean axial elongation was - 0.07 ± 0.15 mm/y in group A, versus 0.32 ± 0.17 mm/y in group B. No statistical differences were observed in HOAs and corneal peripheral defocus at 1, 6, and 12 months (F = 0.653, 0.878; P > 0.05). Multivariate linear regres2025-01-01T00:00:00Z2025 Aug2026-05-10T04:21:32.76Z2026-04-08T01:28:47.054ZS-EPMC123750644084959610.1038/s41598-025-17115-w