{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Panda C"],"pubmed_abstract":["A healthy diet helps transition individuals towards numerous long-term metabolic benefits but is challenging to maintain. Supplementation with additional whole food-based concentrates and herbs may support this shift by enhancing metabolic resilience. This randomized, controlled, crossover study evaluated a 21-day purification program emphasizing plant foods and whole food supplementation on metabolic detoxification, oxidative stress, and gut microbiota composition. Participants followed a plant-based diet for 7 days, with lean proteins introduced from days 8-21. Whole food supplements rich in polyphenols, glucosinolates, and prebiotic fibers were included to support metabolic and gastrointestinal function. The intervention group exhibited 9% (<i>p</i> < 0.0001) reduction in ROS-associated"],"journal":["Frontiers in nutrition"],"pagination":["1621709"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12376428"],"repository":["biostudies-literature"],"pubmed_title":["Metabolic reset purification program improves antioxidant balance and gut microbiome in individuals transitioning to a healthier diet."],"pmcid":["PMC12376428"],"pubmed_authors":["Kruse R","Metzger B","Pourafshar S","Gudavalli M","Williams K","Komarnytsky S","Nance B","Panda C"],"additional_accession":[]},"is_claimable":false,"name":"Metabolic reset purification program improves antioxidant balance and gut microbiome in individuals transitioning to a healthier diet.","description":"A healthy diet helps transition individuals towards numerous long-term metabolic benefits but is challenging to maintain. Supplementation with additional whole food-based concentrates and herbs may support this shift by enhancing metabolic resilience. This randomized, controlled, crossover study evaluated a 21-day purification program emphasizing plant foods and whole food supplementation on metabolic detoxification, oxidative stress, and gut microbiota composition. Participants followed a plant-based diet for 7 days, with lean proteins introduced from days 8-21. Whole food supplements rich in polyphenols, glucosinolates, and prebiotic fibers were included to support metabolic and gastrointestinal function. The intervention group exhibited 9% (<i>p</i> < 0.0001) reduction in ROS-associated","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-07-15T09:45:55.697Z","creation":"2026-07-02T03:12:13.353Z"},"accession":"S-EPMC12376428","cross_references":{"pubmed":["40860479"],"doi":["10.3389/fnut.2025.1621709"]}}