{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li Z"],"funding":["Shaanxi Provincial Science and Technology Development Program","Project of Shaanxi Provincial Science and Technology New Star","National Natural Science Foundation of China","Shaanxi Provincial Key Research and Development Programme"],"pagination":["e02678"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12376516"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(30)"],"pubmed_abstract":["Constructing hydrogels with both remarkable mechanical and self-healing properties is highly desirable for soft electronics, yet remains challenging due to conflicting demands on chemical bonds and polymer chain mobility. Herein, a highly stretchable, self-healing, and conductive gelatin methacryloyl (GelMA) hydrogel is developed by incorporating polyvinyl alcohol, N-(2-amino-2-oxoethyl)-2-propenamide, sodium tetraborate, and sodium chloride into GelMA, followed by a two-step polymerization process. The introduced novel interpenetrating networks, hierarchical hydrogen bonds (weak and strong H-bonds), and borate ester bonds (BEBs) synergistically improve the mechanical strength, and concurrently function as sacrificial bonds for energy dissipation under deformation. Moreover, the constructed reversible BEBs and weak H-bonds enable autonomous self-healing at room temperature. The resulting hydrogel achieves remarkable stretchability (≈160%), tensile strength (≈130 kPa), and self-healing efficiency (86%), surpassing previously reported GelMA hydrogels. Importantly, a self-healing GelMA hydrogel strain sensor is demonstrated, featuring a high gauge factor (≈3.28), ultra-low detection limit (0.1%), and excellent recovery of sensitivity (≈100%) and detection range (≈75%) after damage. Successful monitoring of subtle and large-scale human motions with both original and healed sensors highlights the device's durability and longevity. This study provides a promising approach for the rational design and practical application of GelMA hydrogels in wearable bioelectronics."],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Highly Stretchable, Self-Healable, and Conductive Gelatin Methacryloyl Hydrogel for Long-Lasting Wearable Tactile Sensors."],"pmcid":["PMC12376516"],"funding_grant_id":["52275570","2023KJXX-001","2024RS-CXTD-19","2023-LL-QY-35HZ01","52435010"],"pubmed_authors":["Yu L","Wang B","Jia B","Lu D","Wang J","Qureshi MAK","Zhao Y","Li M","Xue Y","Li Z","Zhao L","Lu J","Han G","Yang P","Zhao K"],"additional_accession":[]},"is_claimable":false,"name":"Highly Stretchable, Self-Healable, and Conductive Gelatin Methacryloyl Hydrogel for Long-Lasting Wearable Tactile Sensors.","description":"Constructing hydrogels with both remarkable mechanical and self-healing properties is highly desirable for soft electronics, yet remains challenging due to conflicting demands on chemical bonds and polymer chain mobility. Herein, a highly stretchable, self-healing, and conductive gelatin methacryloyl (GelMA) hydrogel is developed by incorporating polyvinyl alcohol, N-(2-amino-2-oxoethyl)-2-propenamide, sodium tetraborate, and sodium chloride into GelMA, followed by a two-step polymerization process. The introduced novel interpenetrating networks, hierarchical hydrogen bonds (weak and strong H-bonds), and borate ester bonds (BEBs) synergistically improve the mechanical strength, and concurrently function as sacrificial bonds for energy dissipation under deformation. Moreover, the constructed reversible BEBs and weak H-bonds enable autonomous self-healing at room temperature. The resulting hydrogel achieves remarkable stretchability (≈160%), tensile strength (≈130 kPa), and self-healing efficiency (86%), surpassing previously reported GelMA hydrogels. Importantly, a self-healing GelMA hydrogel strain sensor is demonstrated, featuring a high gauge factor (≈3.28), ultra-low detection limit (0.1%), and excellent recovery of sensitivity (≈100%) and detection range (≈75%) after damage. Successful monitoring of subtle and large-scale human motions with both original and healed sensors highlights the device's durability and longevity. This study provides a promising approach for the rational design and practical application of GelMA hydrogels in wearable bioelectronics.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-09T19:15:04.817Z","creation":"2026-04-08T01:11:01.361Z"},"accession":"S-EPMC12376516","cross_references":{"pubmed":["40439485"],"doi":["10.1002/advs.202502678"]}}