{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Schoch P"],"funding":["European Research Council"],"pagination":["e202506245"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12377431"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["64(35)"],"pubmed_abstract":["Herein, we present the semisynthesis of complex taxane diterpenoid 1-hydroxytaxuspine C. Starting from cheap and abundant 10-deacetylbaccatin III, a scalable and robust route was developed, enabling an unprecedented gram-scale access to the intricate (3,11)-cyclotaxane scaffold. In addition, this represents the first synthetic access to C1-hydroxylated cyclotaxanes. The natural product is synthesized in 17 steps, with the reactions being performed on decagram-scale up to an advanced intermediate, establishing the scalability of this approach."],"journal":["Angewandte Chemie (International ed. in English)"],"pubmed_title":["Gram-Scale Access to (3,11)-Cyclotaxanes-Synthesis of 1-Hydroxytaxuspine C."],"pmcid":["PMC12377431"],"funding_grant_id":["101003072"],"pubmed_authors":["Schoch P","Schneider F","Krivolapova Y","Pan L","Gaich T"],"additional_accession":[]},"is_claimable":false,"name":"Gram-Scale Access to (3,11)-Cyclotaxanes-Synthesis of 1-Hydroxytaxuspine C.","description":"Herein, we present the semisynthesis of complex taxane diterpenoid 1-hydroxytaxuspine C. Starting from cheap and abundant 10-deacetylbaccatin III, a scalable and robust route was developed, enabling an unprecedented gram-scale access to the intricate (3,11)-cyclotaxane scaffold. In addition, this represents the first synthetic access to C1-hydroxylated cyclotaxanes. The natural product is synthesized in 17 steps, with the reactions being performed on decagram-scale up to an advanced intermediate, establishing the scalability of this approach.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-09T19:06:06.227Z","creation":"2026-04-08T01:10:54.65Z"},"accession":"S-EPMC12377431","cross_references":{"pubmed":["40518821"],"doi":["10.1002/anie.202506245"]}}