biostudies-literatureSalminen ABusiness FinlandPfizer Inc.Boehringer Ingelheim International GmbHBiogen MA Inc.Bristol-Myers Squibb CanadaPaulo FoundationAcademy of FinlandGenentech Inc.Bristol Myers Squibb (and Celgene Corporation & Celgene International II Sàrl)Novartis AGGlaxoSmithKline Intellectual Property Development Ltd.Suomen Hammaslääkäriseura ApolloniaNovo Nordisk FondenMaze Therapeutics Inc.Merck Sharp & Dohme LLCSigrid Juséliuksen SäätiöPfizerAstraZeneca UK Ltd.AbbVieAbbVie Inc.NovartisSydäntutkimussäätiöFinnish Foundation for Cardiovascular ResearchPaulon SäätiöSanofi US Services Inc.Janssen Biotech Inc.1263-1275https://www.ebi.ac.uk/biostudies/studies/S-EPMC12377943biostudies-literatureUnknown52(9)<h4>Aim</h4>To perform a genome-wide association study (GWAS) for periodontitis in the FinnGen cohort, as genetic factors contribute to periodontitis.<h4>Materials and methods</h4>We included nearly 250,000 Finnish individuals who had visited a dentist in the public healthcare sector for a clinical oral examination. We designed three periodontitis phenotypes based on diagnosis and procedure codes and CPI indexes in national health registers.<h4>Results</h4>We identified 11 independent genetic loci associated with periodontitis, among which 6 were common and novel. A locus near the FST gene was associated with two phenotypes, whereas other lead SNPs were located near ARL15, MFHAS1, DEFB130A and APOE. Additionally, all phenotypes in the discovery and replication cohorts were associated with Journal of clinical periodontologyGenetic Loci Associated With Periodontitis: The FinnGen Study Based on National Health Registers.PMC123779434685/31/2016UH 4386/31/2016Lahteenmaki SHelminen MKaprio JBiswas SEstrada KHu XHarju TPendergrass RSmaoui NJohn SBlomster TArvas MFinnGenVahatalo IToivola AHart ABing NLaitinen TRodosthenous RAddis LBowers NZiemann ANgo DMakela TPMeretoja TKalliala IXu FHe KAberg FJoensuu HSuominen LSiirtola HPussinen PJSoininen HTachmazidou IMehtonen JTuomi TOllila TKarihtala PMiller MLeinonen RMiller JKambur OSipila KSavukoski SRipatti SRiley-Gills BSalminen EUimari OTurunen JAKytola AWiden EHuertas-Vazquez AReilly DSchleutker JPiltonen THiekkalinna TKettunen JFarias FMishra RWong RYilmaz MHeikinheimo OGanna ALinna MMChung JSalminen AHochfeld MTikkanen JToppila-Salmi SGossel MOllila HKristiansson KSilven HWillberg TKotaniemi-Talonen LElenius KPopovic RLoukola APerola MReeve MPJarvensivu ERemes ATuovila OWaring JKoskelainen SMantyla PTsuo KRaghavan NHedman ALongerich SHassan SKilpelainen EAarnisalo APaajanen TPalin KParkkinen JChen CYPujol NPalin HWeldatsadik RBetts JKoskela JJacob HPaul DPelkonen MKulkarni DBizaki-Vallaskangas AHakanen ANiemi MHavulinna AKahonen MChen HTienari PRaivio TSul JHTasanen KSiltanen SWahlfors TAuvinen PKuopio TStrausz SRinne JRaivio MTeng EKaarniranta KValimaki NLoboda AVirolainen PPlenge RLiu MRivas MPylkas KSliz ETyrmi JMaasha MKlinger KMannikko LSchutzman JUusitalo HTuoken HEhm MGMantere TPalomaki AAnttonen VGhazal AStrauss EHovatta ISipila TPSaarentaus EKallio LAuro KHeyne HGuan MLessard SLuukkaala TO'Donnell CHinttala RPorello ALehto PLiu ASinisalo JMannermaa ALuo SJulkunen VKangasniemi EPunkka EFarkkila MMendelson MKivinen KTammerluoto JDaly MLemmela SCooper HLahesmaa RPulford DNibali LPalotie ASistonen TMars NFabre MLaivuori HViollet CVaura FHuilaja LLaakkonen EAalto-Setala KKalpala KMcCarthy MZheng ZMakela JPalotie UPalotie TMcCarthy LPartanen JLertratanakul AHernesniemi JAaltonen LLaiho PKanai MLaukkanen MLaukkanen JOkafo GMattson JMakitie ARice DPirila LIsomaki PJussila APakkanen RRunz HArffman RSalomaa VLee JBrunfeldt MParolo PDBShen HYSalo TChu ASerpi RLoomis SOller DMaranville JKurra VKilpi TMcDonough SJokimaa VLahtela LEKaunisto MHuhtakangas JKhramtsova EKarjalainen MKarjalainen JJalanko AVaarasmaki MPitkaranta AZhou WEklund KRamo JMalarstig APeltonen SHautalahti MChatelain CCaetano ARenaud NJung MNieminen PTukiainen TAavikko MPitkanen EIsometsa EKosma VMSuvisaari JDada OAKankaanranta HVuoti SPeltola JPikkarainen SRahimov FObeidat MNiinimaki MLlorens VSoutherington TNiiranen TMetsarinne KAittomaki KElliott AWu YPitkanen NEaton SKurki MPadmanabhuni SSRitari JGordillo JETaskinen MRHeikkinen SVoutilainen MHiltunen TAittokallio JZierer JGraham RHiltunen MEicher JMouded MKiiskinen TLu TPetrovski SHannula-Jouppi KKauppi PGordin DSiponen MKaukinen KAuranen ALehtonen ALahdenpera SChoy DLehisto ARahikkala EMorin-Papunen LLehtonen HHyvarinen KCarpen OLi QSWaterworth DDing ZLaisk TSalmi TKaipiainen-Seppanen OKiviniemi MKaiharju EKalviainen RGursoy UKKoulu LRuotsalainen SKajanne RSmith SKumar JPalta PKallionpaa RGarcia-Tabuenca JMattsson HfalseGenetic Loci Associated With Periodontitis: The FinnGen Study Based on National Health Registers.<h4>Aim</h4>To perform a genome-wide association study (GWAS) for periodontitis in the FinnGen cohort, as genetic factors contribute to periodontitis.<h4>Materials and methods</h4>We included nearly 250,000 Finnish individuals who had visited a dentist in the public healthcare sector for a clinical oral examination. We designed three periodontitis phenotypes based on diagnosis and procedure codes and CPI indexes in national health registers.<h4>Results</h4>We identified 11 independent genetic loci associated with periodontitis, among which 6 were common and novel. A locus near the FST gene was associated with two phenotypes, whereas other lead SNPs were located near ARL15, MFHAS1, DEFB130A and APOE. Additionally, all phenotypes in the discovery and replication cohorts were associated with 2025-01-01T00:00:00Z2025 Sep2026-05-10T01:44:12.139Z2026-04-08T01:24:44.177ZS-EPMC123779434068248310.1111/jcpe.14193