biostudies-literatureBi MHong Kong Health and Medical Research Fund (HMRF)National Science Foundation of ChinaHealth and Medical Research Fund1276-1287https://www.ebi.ac.uk/biostudies/studies/S-EPMC12377944biostudies-literatureUnknown52(9)<h4>Background</h4>The diagnostic performance of active matrix metalloproteinase-8 (aMMP-8) point-of-care oral rinse test (POC-ORT) for periodontitis needs to be improved because of its relatively low sensitivity. This study attempted to identify the clinical features associated with the misclassification of periodontal cases by the test.<h4>Method</h4>This work consisted of two cross-sectional diagnostic accuracy studies involving a representative cohort in Hong Kong, China, and a convenience sample of subjects in Shanghai, China. The outcomes of the aMMP-8 POC-ORT (index test) were compared to the case definitions of the 2017 World Workshop on the classification of periodontal health status (reference test). The analysis reports the diagnostic accuracy parameters, the Youden index and coJournal of clinical periodontologyClinical Features Associated With Periodontal Case Misclassification by an Active Matrix Metalloproteinase-8 Point-of-Care Oral Rinse Test.PMC123779448230115707182796Li HLi YPelekos GXie YBi MYu XJin LTonetti MSfalseClinical Features Associated With Periodontal Case Misclassification by an Active Matrix Metalloproteinase-8 Point-of-Care Oral Rinse Test.<h4>Background</h4>The diagnostic performance of active matrix metalloproteinase-8 (aMMP-8) point-of-care oral rinse test (POC-ORT) for periodontitis needs to be improved because of its relatively low sensitivity. This study attempted to identify the clinical features associated with the misclassification of periodontal cases by the test.<h4>Method</h4>This work consisted of two cross-sectional diagnostic accuracy studies involving a representative cohort in Hong Kong, China, and a convenience sample of subjects in Shanghai, China. The outcomes of the aMMP-8 POC-ORT (index test) were compared to the case definitions of the 2017 World Workshop on the classification of periodontal health status (reference test). The analysis reports the diagnostic accuracy parameters, the Youden index and co2025-01-01T00:00:00Z2025 Sep2026-07-15T12:47:29.332Z2026-07-04T03:16:07.091ZS-EPMC123779444046248610.1111/jcpe.14189