biostudies-literatureSilbereisen AVetenskapsrådetSteering Group KI/Region Stockholm for Dental ResearchKarolinska Institutet's Strategic Funds1288-1297https://www.ebi.ac.uk/biostudies/studies/S-EPMC12377945biostudies-literatureUnknown52(9)<h4>Background</h4>This study investigated the diagnostic potential of salivary triggering receptor expressed on myeloid cells (TREM)-1, peptidoglycan recognition protein 1 (PGLYRP1) and interleukin (IL)-1β for periodontitis patients and their ability to predict treatment outcome.<h4>Methods</h4>Systemically healthy, non-smokers with gingivitis (n = 31), stage III periodontitis (34 grade B: n = 34, grade C: n = 24) and healthy controls (n = 34) were recruited. Periodontitis patients (n = 42) underwent non-surgical periodontal treatment. Saliva was collected at baseline (T0) and post-treatment (T1, T3, T6). Biomarkers were measured using immunoassays. Periodontitis patients were categorised into responders (n = 19) and non-responders (n = 23) based on the number of residual pockets ≥ 5 mm wJournal of clinical periodontologyTREM-1 Pathway Biomarkers for Classification of Periodontal Diseases and Monitoring of Treatment Response in Grade B and C Periodontitis.PMC12377945FoUI-9662582021‐035282021-03528FoUI-966140FoUI-990869Emingil GBostanci NAfacan BLira-Junior RSilbereisen AOzturk OVfalseTREM-1 Pathway Biomarkers for Classification of Periodontal Diseases and Monitoring of Treatment Response in Grade B and C Periodontitis.<h4>Background</h4>This study investigated the diagnostic potential of salivary triggering receptor expressed on myeloid cells (TREM)-1, peptidoglycan recognition protein 1 (PGLYRP1) and interleukin (IL)-1β for periodontitis patients and their ability to predict treatment outcome.<h4>Methods</h4>Systemically healthy, non-smokers with gingivitis (n = 31), stage III periodontitis (34 grade B: n = 34, grade C: n = 24) and healthy controls (n = 34) were recruited. Periodontitis patients (n = 42) underwent non-surgical periodontal treatment. Saliva was collected at baseline (T0) and post-treatment (T1, T3, T6). Biomarkers were measured using immunoassays. Periodontitis patients were categorised into responders (n = 19) and non-responders (n = 23) based on the number of residual pockets ≥ 5 mm w2025-01-01T00:00:00Z2025 Sep2026-05-10T01:45:55.028Z2026-04-08T01:25:00.602ZS-EPMC123779454052865010.1111/jcpe.14195