{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sunthankar SD"],"funding":["NCATS NIH HHS","NICHD NIH HHS","FDA HHS"],"pagination":["e1470-e1480"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12378003"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["53(7)"],"pubmed_abstract":["<h4>Objectives</h4>Evaluate benefits and harms of prophylactic intraoperative methylprednisolone in subpopulations undergoing infant heart surgery.<h4>Design</h4>Subpopulation analyses of The Steroids to Reduce Systemic Inflammation after Infant Heart Surgery (STRESS) trial, a double-blind randomized placebo-controlled trial.<h4>Setting</h4>Twenty-four congenital heart centers.<h4>Patients</h4>Infants (< 1 yr old) undergoing heart surgery with cardiopulmonary bypass. Patients stratified by Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery Congenital Heart Surgery (STAT) mortality category, age, gestational age, and presence of chromosomal or syndromic diagnosis (CSD).<h4>Interventions</h4>Methylprednisolone (30 mg/kg) vs. placebo administered into cardiopulmonar"],"journal":["Critical care medicine"],"pubmed_title":["Methylprednisolone for Infant Heart Surgery: Subpopulation Analyses of a Randomized Controlled Trial."],"pmcid":["PMC12378003"],"funding_grant_id":["U24 TR001608","HHSN275201800003I","P50 HD106446","U18 FD006298","U01 TR001803"],"pubmed_authors":["Sunthankar SD","Karamlou T","Van Bergen AH","Vener DF","Anderson BR","Bleiweis MS","Hill KD","Scott JP","Kannankeril PJ","Jacobs ML","Benscoter A","Baldwin HS","Alfieris G","Mettler B","Li JS","Jacobs JP","Graham EM","Eghtesady P","Blasiole B","Wald E","Husain SA"],"additional_accession":[]},"is_claimable":false,"name":"Methylprednisolone for Infant Heart Surgery: Subpopulation Analyses of a Randomized Controlled Trial.","description":"<h4>Objectives</h4>Evaluate benefits and harms of prophylactic intraoperative methylprednisolone in subpopulations undergoing infant heart surgery.<h4>Design</h4>Subpopulation analyses of The Steroids to Reduce Systemic Inflammation after Infant Heart Surgery (STRESS) trial, a double-blind randomized placebo-controlled trial.<h4>Setting</h4>Twenty-four congenital heart centers.<h4>Patients</h4>Infants (< 1 yr old) undergoing heart surgery with cardiopulmonary bypass. Patients stratified by Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery Congenital Heart Surgery (STAT) mortality category, age, gestational age, and presence of chromosomal or syndromic diagnosis (CSD).<h4>Interventions</h4>Methylprednisolone (30 mg/kg) vs. placebo administered into cardiopulmonar","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jul","modification":"2026-05-09T17:56:05.527Z","creation":"2026-04-08T01:08:44.212Z"},"accession":"S-EPMC12378003","cross_references":{"pubmed":["40396812"],"doi":["10.1097/ccm.0000000000006721","10.1097/CCM.0000000000006721"]}}