biostudies-literatureSunthankar SDNCATS NIH HHSNICHD NIH HHSFDA HHSe1470-e1480https://www.ebi.ac.uk/biostudies/studies/S-EPMC12378003biostudies-literatureUnknown53(7)<h4>Objectives</h4>Evaluate benefits and harms of prophylactic intraoperative methylprednisolone in subpopulations undergoing infant heart surgery.<h4>Design</h4>Subpopulation analyses of The Steroids to Reduce Systemic Inflammation after Infant Heart Surgery (STRESS) trial, a double-blind randomized placebo-controlled trial.<h4>Setting</h4>Twenty-four congenital heart centers.<h4>Patients</h4>Infants (< 1 yr old) undergoing heart surgery with cardiopulmonary bypass. Patients stratified by Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery Congenital Heart Surgery (STAT) mortality category, age, gestational age, and presence of chromosomal or syndromic diagnosis (CSD).<h4>Interventions</h4>Methylprednisolone (30 mg/kg) vs. placebo administered into cardiopulmonarCritical care medicineMethylprednisolone for Infant Heart Surgery: Subpopulation Analyses of a Randomized Controlled Trial.PMC12378003U24 TR001608HHSN275201800003IP50 HD106446U18 FD006298U01 TR001803Sunthankar SDKaramlou TVan Bergen AHVener DFAnderson BRBleiweis MSHill KDScott JPKannankeril PJJacobs MLBenscoter ABaldwin HSAlfieris GMettler BLi JSJacobs JPGraham EMEghtesady PBlasiole BWald EHusain SAfalseMethylprednisolone for Infant Heart Surgery: Subpopulation Analyses of a Randomized Controlled Trial.<h4>Objectives</h4>Evaluate benefits and harms of prophylactic intraoperative methylprednisolone in subpopulations undergoing infant heart surgery.<h4>Design</h4>Subpopulation analyses of The Steroids to Reduce Systemic Inflammation after Infant Heart Surgery (STRESS) trial, a double-blind randomized placebo-controlled trial.<h4>Setting</h4>Twenty-four congenital heart centers.<h4>Patients</h4>Infants (< 1 yr old) undergoing heart surgery with cardiopulmonary bypass. Patients stratified by Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery Congenital Heart Surgery (STAT) mortality category, age, gestational age, and presence of chromosomal or syndromic diagnosis (CSD).<h4>Interventions</h4>Methylprednisolone (30 mg/kg) vs. placebo administered into cardiopulmonar2025-01-01T00:00:00Z2025 Jul2026-05-09T17:56:05.527Z2026-04-08T01:08:44.212ZS-EPMC123780034039681210.1097/ccm.000000000000672110.1097/CCM.0000000000006721