{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(36)"],"submitter":["Peng R"],"pubmed_abstract":["Metabolic inflammation (metaflammation) may occur throughout the body and evolve into various metabolic syndromes, so developing a universal approach for diagnosing and treating metaflammation is meaningful. Here, we developed a single-walled carbon nanotube (SWNT)-based photothermal shock therapy (PTST) for photoacoustic image-guided therapy of metaflammation. Mechanistically, SWNTs are specifically taken up by Ly-6C<sup>hi</sup> monocytes in peripheral blood and then rerouted to inflamed tissues <i>via</i> Ly-6C<sup>hi</sup> monocyte hitchhiking. Due to the accumulation of SWNTs, inflamed tissues can be distinguished by photoacoustic imaging. For treating metaflammation, inflamed tissue gated by photoacoustic imaging is irradiated with near-infrared light and heated to heat shock tempera"],"journal":["Chemical science"],"pagination":["16936-16946"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12378547"],"repository":["biostudies-literature"],"pubmed_title":["Single-walled carbon nanotubes hitchhike on Ly-6C&lt;sup&gt;hi&lt;/sup&gt; monocytes for photoacoustic image-guided photothermal shock therapy of metabolic inflammation."],"pmcid":["PMC12378547"],"pubmed_authors":["Jiang J","Peng R","Tang LJ","He M","Chu X","Yuan Y"],"additional_accession":[]},"is_claimable":false,"name":"Single-walled carbon nanotubes hitchhike on Ly-6C&lt;sup&gt;hi&lt;/sup&gt; monocytes for photoacoustic image-guided photothermal shock therapy of metabolic inflammation.","description":"Metabolic inflammation (metaflammation) may occur throughout the body and evolve into various metabolic syndromes, so developing a universal approach for diagnosing and treating metaflammation is meaningful. Here, we developed a single-walled carbon nanotube (SWNT)-based photothermal shock therapy (PTST) for photoacoustic image-guided therapy of metaflammation. Mechanistically, SWNTs are specifically taken up by Ly-6C<sup>hi</sup> monocytes in peripheral blood and then rerouted to inflamed tissues <i>via</i> Ly-6C<sup>hi</sup> monocyte hitchhiking. Due to the accumulation of SWNTs, inflamed tissues can be distinguished by photoacoustic imaging. For treating metaflammation, inflamed tissue gated by photoacoustic imaging is irradiated with near-infrared light and heated to heat shock tempera","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-02T20:34:03.377Z","creation":"2026-05-27T03:08:00.773Z"},"accession":"S-EPMC12378547","cross_references":{"pubmed":["40880795"],"doi":["10.1039/d5sc05091j"]}}