biostudies-literatureUnknown16(36)Peng RMetabolic inflammation (metaflammation) may occur throughout the body and evolve into various metabolic syndromes, so developing a universal approach for diagnosing and treating metaflammation is meaningful. Here, we developed a single-walled carbon nanotube (SWNT)-based photothermal shock therapy (PTST) for photoacoustic image-guided therapy of metaflammation. Mechanistically, SWNTs are specifically taken up by Ly-6C^hi monocytes in peripheral blood and then rerouted to inflamed tissues <i>via</i> Ly-6C^hi monocyte hitchhiking. Due to the accumulation of SWNTs, inflamed tissues can be distinguished by photoacoustic imaging. For treating metaflammation, inflamed tissue gated by photoacoustic imaging is irradiated with near-infrared light and heated to heat shock temperaChemical science16936-16946https://www.ebi.ac.uk/biostudies/studies/S-EPMC12378547biostudies-literatureSingle-walled carbon nanotubes hitchhike on Ly-6C&lt;sup&gt;hi&lt;/sup&gt; monocytes for photoacoustic image-guided photothermal shock therapy of metabolic inflammation.PMC12378547Jiang JPeng RTang LJHe MChu XYuan YfalseSingle-walled carbon nanotubes hitchhike on Ly-6C&lt;sup&gt;hi&lt;/sup&gt; monocytes for photoacoustic image-guided photothermal shock therapy of metabolic inflammation.Metabolic inflammation (metaflammation) may occur throughout the body and evolve into various metabolic syndromes, so developing a universal approach for diagnosing and treating metaflammation is meaningful. Here, we developed a single-walled carbon nanotube (SWNT)-based photothermal shock therapy (PTST) for photoacoustic image-guided therapy of metaflammation. Mechanistically, SWNTs are specifically taken up by Ly-6C^hi monocytes in peripheral blood and then rerouted to inflamed tissues <i>via</i> Ly-6C^hi monocyte hitchhiking. Due to the accumulation of SWNTs, inflamed tissues can be distinguished by photoacoustic imaging. For treating metaflammation, inflamed tissue gated by photoacoustic imaging is irradiated with near-infrared light and heated to heat shock tempera2025-01-01T00:00:00Z2025 Sep2026-06-02T20:34:03.377Z2026-05-27T03:08:00.773ZS-EPMC123785474088079510.1039/d5sc05091j