{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(4)"],"submitter":["van Poelgeest E"],"pubmed_abstract":["<h4>Background</h4>Healthcare providers should balance the potential risks and benefits of chronic diuretic use, particularly in older adults, as with age, diuretic benefits may decline and risks increase. A comprehensive synthesis and critical evaluation of the available evidence on chronic diuretic treatment effects is currently lacking.<h4>Methods</h4>We conducted an umbrella review of systematic reviews and meta-analyses published since 2018 on health outcomes associated with diuretic use in randomized-controlled trials (RCTs). We conducted random-effects meta-analysis for pooled effect estimates and narratively summarized data that could not be pooled.<h4>Results</h4>We included 741 effect estimations from 117 systematic reviews (SRs) on 1566 RCTs in individuals aged 62 ± 6 years. Of "],"journal":["European geriatric medicine"],"pagination":["1353-1387"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12378697"],"repository":["biostudies-literature"],"pubmed_title":["Effectiveness and safety of chronic diuretic use in older adults: an umbrella review of recently published systematic reviews and meta-analyses of randomized-controlled trials."],"pmcid":["PMC12378697"],"pubmed_authors":["Piotrowicz K","Daams J","Cherubini A","Eidam A","Gasowski J","Prokopidis K","Beccacece A","Paoletti L","Testa GD","Kwak MJ","Bahat G","Topinkova E","Ilhan B","van der Velde N","van Poelgeest E","Goyal P","European Geriatric Medicine Society Special Interest Groups of i. Pharmacology; ii. Cardiovascular Disease and iii. Systematic Review and Meta-analysis","Erdogan T","Kocak FOK","Soulis G","Ozkok S","Handoko ML","Veronese N","Thompson W"],"additional_accession":[]},"is_claimable":false,"name":"Effectiveness and safety of chronic diuretic use in older adults: an umbrella review of recently published systematic reviews and meta-analyses of randomized-controlled trials.","description":"<h4>Background</h4>Healthcare providers should balance the potential risks and benefits of chronic diuretic use, particularly in older adults, as with age, diuretic benefits may decline and risks increase. A comprehensive synthesis and critical evaluation of the available evidence on chronic diuretic treatment effects is currently lacking.<h4>Methods</h4>We conducted an umbrella review of systematic reviews and meta-analyses published since 2018 on health outcomes associated with diuretic use in randomized-controlled trials (RCTs). We conducted random-effects meta-analysis for pooled effect estimates and narratively summarized data that could not be pooled.<h4>Results</h4>We included 741 effect estimations from 117 systematic reviews (SRs) on 1566 RCTs in individuals aged 62 ± 6 years. Of ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-10T01:51:47.162Z","creation":"2026-04-08T01:25:59.29Z"},"accession":"S-EPMC12378697","cross_references":{"pubmed":["40413712"],"doi":["10.1007/s41999-025-01229-5"]}}