biostudies-literatureUnknown16(4)van Poelgeest E<h4>Background</h4>Healthcare providers should balance the potential risks and benefits of chronic diuretic use, particularly in older adults, as with age, diuretic benefits may decline and risks increase. A comprehensive synthesis and critical evaluation of the available evidence on chronic diuretic treatment effects is currently lacking.<h4>Methods</h4>We conducted an umbrella review of systematic reviews and meta-analyses published since 2018 on health outcomes associated with diuretic use in randomized-controlled trials (RCTs). We conducted random-effects meta-analysis for pooled effect estimates and narratively summarized data that could not be pooled.<h4>Results</h4>We included 741 effect estimations from 117 systematic reviews (SRs) on 1566 RCTs in individuals aged 62 ± 6 years. Of European geriatric medicine1353-1387https://www.ebi.ac.uk/biostudies/studies/S-EPMC12378697biostudies-literatureEffectiveness and safety of chronic diuretic use in older adults: an umbrella review of recently published systematic reviews and meta-analyses of randomized-controlled trials.PMC12378697Piotrowicz KDaams JCherubini AEidam AGasowski JProkopidis KBeccacece APaoletti LTesta GDKwak MJBahat GTopinkova EIlhan Bvan der Velde Nvan Poelgeest EGoyal PEuropean Geriatric Medicine Society Special Interest Groups of i. Pharmacology; ii. Cardiovascular Disease and iii. Systematic Review and Meta-analysisErdogan TKocak FOKSoulis GOzkok SHandoko MLVeronese NThompson WfalseEffectiveness and safety of chronic diuretic use in older adults: an umbrella review of recently published systematic reviews and meta-analyses of randomized-controlled trials.<h4>Background</h4>Healthcare providers should balance the potential risks and benefits of chronic diuretic use, particularly in older adults, as with age, diuretic benefits may decline and risks increase. A comprehensive synthesis and critical evaluation of the available evidence on chronic diuretic treatment effects is currently lacking.<h4>Methods</h4>We conducted an umbrella review of systematic reviews and meta-analyses published since 2018 on health outcomes associated with diuretic use in randomized-controlled trials (RCTs). We conducted random-effects meta-analysis for pooled effect estimates and narratively summarized data that could not be pooled.<h4>Results</h4>We included 741 effect estimations from 117 systematic reviews (SRs) on 1566 RCTs in individuals aged 62 ± 6 years. Of 2025-01-01T00:00:00Z2025 Aug2026-05-10T01:51:47.162Z2026-04-08T01:25:59.29ZS-EPMC123786974041371210.1007/s41999-025-01229-5