{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cheng YY"],"funding":["En Chu Kong Hospital","Taipei Veterans General Hospital","National Science and Technology Council","CGMH-NYCU Joint Research Program","China Medical University"],"pagination":["67"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12379366"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["Carbapenem-resistant Escherichia coli (CREC) can cause persistent or multi-site infections, leading to significant clinical challenges due to the limited availability of effective antibiotics. However, the within-host evolution of CREC and its impact on infection patterns remain poorly understood. This study aims to characterize CREC isolates from patients with recurrent or multi-site infections to elucidate the relationship between bacterial adaptation within the host and infection dynamics, thereby addressing a critical gap in our understanding of CREC pathogenesis. Genotypic analysis, including Nanopore whole-genome sequencing, and phenotypic comparisons were performed on CREC isolates from individual patients. Pulsed-field gel electrophoresis (PFGE) patterns revealed that 18 patients w"],"journal":["Gut pathogens"],"pubmed_title":["Tracing the evolutionary dynamics of carbapenem-resistant Escherichia coli in recurrent and multi-site infections."],"pmcid":["PMC12379366"],"funding_grant_id":["CGMH-NYCU-113-CORPG8P0211","CMU113-N-14","ECKH_W11201","V113C-200","112-2320-B-A49-045-MY3"],"pubmed_authors":["Fan YH","Zhang YZ","Tsai YM","Ho DZ","Chen YC","Cheng YY","Lee YH","Wang MC","Thuy TTD","Kao CY","Teng CH","Kuo PY","Bregente CJB","Chuang YC"],"additional_accession":[]},"is_claimable":false,"name":"Tracing the evolutionary dynamics of carbapenem-resistant Escherichia coli in recurrent and multi-site infections.","description":"Carbapenem-resistant Escherichia coli (CREC) can cause persistent or multi-site infections, leading to significant clinical challenges due to the limited availability of effective antibiotics. However, the within-host evolution of CREC and its impact on infection patterns remain poorly understood. This study aims to characterize CREC isolates from patients with recurrent or multi-site infections to elucidate the relationship between bacterial adaptation within the host and infection dynamics, thereby addressing a critical gap in our understanding of CREC pathogenesis. Genotypic analysis, including Nanopore whole-genome sequencing, and phenotypic comparisons were performed on CREC isolates from individual patients. Pulsed-field gel electrophoresis (PFGE) patterns revealed that 18 patients w","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-28T02:20:25.103Z","creation":"2026-04-08T02:07:59.633Z"},"accession":"S-EPMC12379366","cross_references":{"pubmed":["40859410"],"doi":["10.1186/s13099-025-00746-9"]}}