biostudies-literatureYang YNational Key Research and Development Program of China1124https://www.ebi.ac.uk/biostudies/studies/S-EPMC12379510biostudies-literatureUnknown25(1)BACKGROUND SRS: (Short Internodes/Stylish/SHI-Related Sequence) genes play a crucial role in plant developments, encompassing organ morphogenesis. However, at present, the biological significance of potato StSRS genes remains unknown. This study comprehensively identified and analysed the potential functions of StSRS genes in potato tuberization. RESULTS: Through phylogenetic and conserved motif analyses, eight members of the StSRS family were successfully identified and classified into five distinct subfamilies. The intraspecies and interspecies collinearity analyses offered insights into the evolutionary clues of the StSRS family, showing closer homology to tomato and tobacco. High-quality RNA-sequencing (Q30 > 97.16%) revealed dynamic gene expression profiles, with 146 to 997 differentiBMC plant biologyThe potential role of short internodes/stylish (SHI/STY) and SHI related sequence (SRS) in potato tuberization.PMC123795102022YFD1201600, 2022YFD1601404Shahzad ALi YYang YLiang FWu LLiao XZheng LGul HLv DYe YGul SXu ZfalseThe potential role of short internodes/stylish (SHI/STY) and SHI related sequence (SRS) in potato tuberization.BACKGROUND SRS: (Short Internodes/Stylish/SHI-Related Sequence) genes play a crucial role in plant developments, encompassing organ morphogenesis. However, at present, the biological significance of potato StSRS genes remains unknown. This study comprehensively identified and analysed the potential functions of StSRS genes in potato tuberization. RESULTS: Through phylogenetic and conserved motif analyses, eight members of the StSRS family were successfully identified and classified into five distinct subfamilies. The intraspecies and interspecies collinearity analyses offered insights into the evolutionary clues of the StSRS family, showing closer homology to tomato and tobacco. High-quality RNA-sequencing (Q30 > 97.16%) revealed dynamic gene expression profiles, with 146 to 997 differenti2025-01-01T00:00:00Z2025 Aug2026-04-08T10:23:57.524Z2026-04-08T01:24:54.658ZS-EPMC123795104085526910.1186/s12870-025-07172-8