biostudies-literatureUnknown20(1)Bougioukas LLye ingestion or other esophageal trauma may require surgical reconstruction. The hypopharyngeal anastomosis during esophageal reconstruction is a technically demanding procedure with many nuances in approach. Patients often have a challenging post-operative course, and few regain the ability to tolerate a normal diet. We describe a case series of three patients (2 colon interpositions and 1 gastric pull-up) who underwent esophageal reconstruction with a hypopharyngeal anastomosis at our institution from years 2017 to 2024, then review the literature. We recommend a multidisciplinary team approach with otolaryngology and/or general surgery for the neck dissection and preparation of the conduit. For the hypopharyngeal anastomosis, we recommend a two-layer, interrupted suture method to the left, lateral piriform sinus along with careful laryngeal nerve preservation. Patients require close follow-up for endoscopic therapy to treat the often-inevitable dysphagia after surgery. All three patients survived and had improved swallow function after surgery.Journal of cardiothoracic surgery345https://www.ebi.ac.uk/biostudies/studies/S-EPMC12379545biostudies-literatureEsophageal reconstruction using a hypopharyngeal anastomosis - a single center experience with review of the literature.PMC12379545Zeltsman DWeiss MJJurado JEHyman KMLee PCGlassman LRBougioukas LPereira LMfalseEsophageal reconstruction using a hypopharyngeal anastomosis - a single center experience with review of the literature.Lye ingestion or other esophageal trauma may require surgical reconstruction. The hypopharyngeal anastomosis during esophageal reconstruction is a technically demanding procedure with many nuances in approach. Patients often have a challenging post-operative course, and few regain the ability to tolerate a normal diet. We describe a case series of three patients (2 colon interpositions and 1 gastric pull-up) who underwent esophageal reconstruction with a hypopharyngeal anastomosis at our institution from years 2017 to 2024, then review the literature. We recommend a multidisciplinary team approach with otolaryngology and/or general surgery for the neck dissection and preparation of the conduit. For the hypopharyngeal anastomosis, we recommend a two-layer, interrupted suture method to the left, lateral piriform sinus along with careful laryngeal nerve preservation. Patients require close follow-up for endoscopic therapy to treat the often-inevitable dysphagia after surgery. All three patients survived and had improved swallow function after surgery.2025-01-01T00:00:00Z2025 Aug2026-05-28T02:19:35.082Z2026-04-08T02:07:43.39ZS-EPMC123795454085937410.1186/s13019-025-03575-8