{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang Y"],"funding":["Scientific and Technological Research Program of Chongqing Municipal Education Commission","National Natural Science Foundation of China"],"pagination":["e1011837"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12380352"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(8)"],"pubmed_abstract":["Insects undergo periodic ecdysis to shed their old chitinous exoskeleton and form a new cuticular layer. The steroid hormone 20-hydroxyecdysone (20E) is widely recognized as a central regulator of insect molting. Acting as a signaling molecule, 20E pulses orchestrate gene expression in a concentration- and time-dependent fashion. However, investigations into the transcriptomic and epigenomic alterations linked to dynamic 20E fluctuations remain limited. In this study, we explored the temporal dynamics of epidermal transcriptomes and genome-wide chromatin accessibility during the larval-larval molting cycle of the silkworm, Bombyx mori. Our results unveiled pronounced shifts in gene expression and chromatin architecture between early and late molting stages, correlating with ascending and d"],"journal":["PLoS genetics"],"pubmed_title":["Transcriptomic landscape and chromatin accessibility uncover pivotal regulators driving programmed larval-larval molting in the domesticated silkworm."],"pmcid":["PMC12380352"],"funding_grant_id":["31772527","KJZD-K202200507","32070499"],"pubmed_authors":["Yang X","Ling X","Zhang Z","Hong J","Sun W","Wang Y","Li L","Qiao L"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptomic landscape and chromatin accessibility uncover pivotal regulators driving programmed larval-larval molting in the domesticated silkworm.","description":"Insects undergo periodic ecdysis to shed their old chitinous exoskeleton and form a new cuticular layer. The steroid hormone 20-hydroxyecdysone (20E) is widely recognized as a central regulator of insect molting. Acting as a signaling molecule, 20E pulses orchestrate gene expression in a concentration- and time-dependent fashion. However, investigations into the transcriptomic and epigenomic alterations linked to dynamic 20E fluctuations remain limited. In this study, we explored the temporal dynamics of epidermal transcriptomes and genome-wide chromatin accessibility during the larval-larval molting cycle of the silkworm, Bombyx mori. Our results unveiled pronounced shifts in gene expression and chromatin architecture between early and late molting stages, correlating with ascending and d","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-05-10T04:24:44.189Z","creation":"2026-04-08T01:28:46.354Z"},"accession":"S-EPMC12380352","cross_references":{"pubmed":["40828865"],"doi":["10.1371/journal.pgen.1011837"]}}